Exploring the resistance mechanism of triple-negative breast cancer to paclitaxel through the scRNA-seq analysis

W Gao, L Sun, J Gai, Y Cao, S Zhang - Plos one, 2024 - journals.plos.org
Background The triple negative breast cancer (TNBC) is the most malignant subtype of
breast cancer with high aggressiveness. Although paclitaxel-based chemotherapy scenario …

[HTML][HTML] Truncated HDAC9 identified by integrated genome-wide screen as the key modulator for paclitaxel resistance in triple-negative breast cancer

B Lian, YC Pei, YZ Jiang, MZ Xue, DQ Li, XG Li… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Paclitaxel resistance is a major concern when treating triple-negative breast
cancer (TNBC) patients. We aimed to identify candidates causing paclitaxel resistance and …

[HTML][HTML] Identified the novel resistant biomarkers for taxane-based therapy for triple-negative breast cancer

CW Chou, YM Huang, YJ Chang… - … journal of medical …, 2021 - ncbi.nlm.nih.gov
Developing treatment strategies for triple-negative breast cancer (TNBC) has become an
important clinical challenge. Currently, taxane-based chemotherapy is one of the standard …

[PDF][PDF] New insights in gene expression alteration as effect of paclitaxel drug resistance in triple negative breast cancer cells

A Jurj, LA Pop, O Zanoaga… - Cell. Physiol …, 2020 - pdfs.semanticscholar.org
Abstract Background/Aims: Triple negative breast cancer (TNBC) is a highly aggressive form
of cancer which lacks targeted therapy options. Thus, TNBC patients have poor outcomes …

Paclitaxel resistance modulated by the interaction between TRPS1 and AF178030. 2 in triple‐negative breast cancer

T Zhao, T Zhang, Y Zhang, B Zhou… - … and Alternative Medicine, 2022 - Wiley Online Library
Paclitaxel is a chemotherapeutic agent that acts as an inhibitor of cellular mitosis and has
been widely used in the treatment of triple‐negative breast cancer (TNBC). However …

Kinome-wide siRNA screening identifies Src-enhanced resistance of chemotherapeutic drugs in triple-negative breast cancer cells

YDT Tzeng, PF Liu, JY Li, LF Liu, SY Kuo… - Frontiers in …, 2018 - frontiersin.org
Background: Chemotherapy is the main treatment for triple-negative breast cancer (TNBC),
which lack molecular markers for diagnosis and therapy. Cancer cells activate …

Differential expression and pathway analysis in drug-resistant triple-negative breast cancer cell lines using RNASeq analysis

S Shaheen, F Fawaz, S Shah… - International journal of …, 2018 - mdpi.com
Triple-negative breast cancer (TNBC) is among the most notorious types of breast cancer,
the treatment of which does not give consistent results due to the absence of the three …

Identification of New Chemoresistance-Associated Genes in Triple-Negative Breast Cancer by Single-Cell Transcriptomic Analysis

S Foutadakis, D Kordias, G Vatsellas… - International Journal of …, 2024 - mdpi.com
Triple-negative breast cancer (TNBC) is a particularly aggressive mammary neoplasia with a
high fatality rate, mainly because of the development of resistance to administered …

[HTML][HTML] SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer

XY Liu, W Jiang, D Ma, LP Ge, YS Yang, ZC Gou… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Taxanes are frontline chemotherapeutic drugs for patients with triple-negative
breast cancer (TNBC); however, chemoresistance reduces their effectiveness. We …

RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells

JA Bauer, F Ye, CB Marshall, BD Lehmann… - Breast Cancer …, 2010 - Springer
Introduction Paclitaxel is a widely used drug in the treatment of patients with locally
advanced and metastatic breast cancer. However, only a small portion of patients have a …