Extracellular vesicles derived from neural stem cells, astrocytes, and microglia as therapeutics for easing TBI-induced brain dysfunction

C Hering, AK Shetty - Stem cells translational medicine, 2023 - academic.oup.com
Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs),
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …

Extracellular vesicles mediate neuroprotection and functional recovery after traumatic brain injury

MK Sun, AP Passaro, CF Latchoumane… - Journal of …, 2020 - liebertpub.com
The lack of effective therapies for moderate-to-severe traumatic brain injuries (TBIs) leaves
patients with lifelong disabilities. Neural stem cells (NSCs) have demonstrated great …

Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration

Y Xiong, A Mahmood, M Chopp - Neural Regeneration Research, 2024 - journals.lww.com
Traumatic brain injury is a serious and complex neurological condition that affects millions of
people worldwide. Despite significant advancements in the field of medicine, effective …

Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression

TR Doeppner, J Herz, A Görgens… - Stem cells …, 2015 - academic.oup.com
Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent
evidence has suggested that stem and progenitor cells alike promote postischemic …

[HTML][HTML] Stem cell-derived extracellular vesicle therapy for acute brain insults and neurodegenerative diseases

OY Bang, JE Kim - BMB reports, 2022 - ncbi.nlm.nih.gov
Stem cell-based therapy is a promising approach for treating a variety of disorders, including
acute brain insults and neurodegenerative diseases. Stem cells such as mesenchymal stem …

Effects of neural stem cell‐derived extracellular vesicles on neuronal protection and functional recovery in the rat model of middle cerebral artery occlusion

M Mahdavipour, G Hassanzadeh… - Cell biochemistry …, 2020 - Wiley Online Library
Stroke imposes a long‐term neurological disability with limited effective treatments available
for neuronal recovery. Transplantation of neural stem cells (NSCs) is reported to improve …

Extracellular vesicles as therapeutics for brain injury and disease

D Upadhya, AK Shetty - Current Pharmaceutical Design, 2019 - ingentaconnect.com
Extracellular vesicles (EVs) are gaining tremendous importance in comprehending central
nervous system (CNS) function and treating neurological disorders because of their role in …

Extracellular vesicles derived from neural progenitor cells––a preclinical evaluation for stroke treatment in mice

X Zheng, L Zhang, Y Kuang, V Venkataramani… - Translational stroke …, 2021 - Springer
Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in
preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports …

MSCs-derived exosomes and neuroinflammation, neurogenesis and therapy of traumatic brain injury

Y Yang, Y Ye, X Su, J He, W Bai, X He - Frontiers in cellular …, 2017 - frontiersin.org
Exosomes are endosomal origin membrane-enclosed small vesicles (30–100 nm) that
contain various molecular constituents including proteins, lipids, mRNAs and microRNAs …

Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy

Y Rong, W Liu, J Wang, J Fan, Y Luo, L Li, F Kong… - Cell death & …, 2019 - nature.com
Spinal cord injury (SCI) can cause severe irreversible motor dysfunction and even death.
Neural stem cell (NSC) transplantation can promote functional recovery after acute SCI in …