Anisotropic stiffness gradient-regulated mechanical guidance drives directional migration of cancer cells
Interfacial interactions between cancer cells and surrounding microenvironment involve
complex mechanotransduction mechanisms that are directly associated with tumor invasion …
complex mechanotransduction mechanisms that are directly associated with tumor invasion …
Extracellular matrix mechanobiology in cancer cell migration
The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
Directional cues in the tumor microenvironment due to cell contraction against aligned collagen fibers
JM Szulczewski, DR Inman, M Proestaki, J Notbohm… - Acta biomaterialia, 2021 - Elsevier
It is well established that collagen alignment in the breast tumor microenvironment provides
biophysical cues to drive disease progression. Numerous mechanistic studies have …
biophysical cues to drive disease progression. Numerous mechanistic studies have …
Breast cancer cells mechanosensing in engineered matrices: Correlation with aggressive phenotype
The pathogenesis of cancer is often driven by the modulation of the tumor
microenvironment. Recent reports have highlighted that the progressive stiffening of tumor …
microenvironment. Recent reports have highlighted that the progressive stiffening of tumor …
3D In Vitro Models for Investigating the Role of Stiffness in Cancer Invasion
A Micalet, E Moeendarbary… - ACS Biomaterials Science …, 2021 - ACS Publications
Background: Tumorigenesis is attributed to the interactions of cancer cells with the tumor
microenvironment through both biochemical cues and physical stimuli. Increased matrix …
microenvironment through both biochemical cues and physical stimuli. Increased matrix …
Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential
Increased tissue stiffness is a classic characteristic of solid tumors. One of the major
contributing factors is increased density of collagen fibers in the extracellular matrix (ECM) …
contributing factors is increased density of collagen fibers in the extracellular matrix (ECM) …
[PDF][PDF] Bio-inspired mechanotactic hybrids for orchestrating traction-mediated epithelial migration
DOI: 10.1002/adma. 201505300 of mechanotactic behaviors has been conceived, in such
processes as cancer metastasis and bone remodeling, which refers to directed cell …
processes as cancer metastasis and bone remodeling, which refers to directed cell …
Substrate stiffness orchestrates epithelial cellular heterogeneity with controlled proliferative pattern via E-cadherin/β-catenin mechanotransduction
B Wang, P Qin, H Zhao, T Xia, J Wang, L Liu, L Zhu… - Acta biomaterialia, 2016 - Elsevier
Epithelial cellular heterogeneity has been observed in pathological tissues with abnormal
matrix stiffness and cells cultured on rigid substrates. However, it remains unclear how …
matrix stiffness and cells cultured on rigid substrates. However, it remains unclear how …
Purse-string contraction guides mechanical gradient-dictated heterogeneous migration of epithelial monolayer
Mechanical heterogeneity has been recognized as an important role in mediating collective
cell migration, yet the related mechanism has not been elucidated. Herein, we fabricate …
cell migration, yet the related mechanism has not been elucidated. Herein, we fabricate …
Fiber microarchitecture in interpenetrating collagen–alginate hydrogel with tunable mechanical plasticity regulates tumor cell migration
Z Wei, J Liu, Y Jia, M Lei, S Zhang, P Xi… - Advanced …, 2023 - Wiley Online Library
The fiber structures of tumor microenvironment (TME) are well‐known in regulating tumor
cell behaviors, and the plastic remolding of TME has recently been suggested to enhance …
cell behaviors, and the plastic remolding of TME has recently been suggested to enhance …