The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches

NK Prabhakar, H Khan, AK Grewal, TG Singh - International …, 2022 - Elsevier
TBI has been one of the top causes of death and morbidity worldwide, yet despite enormous
efforts to discover neuroprotective therapeutics for this serious disease, no beneficial …

Therapies negating neuroinflammation after brain trauma

S Hellewell, BD Semple, MC Morganti-Kossmann - Brain research, 2016 - Elsevier
Traumatic brain injury (TBI) elicits a complex secondary injury response, with
neuroinflammation as a crucial central component. Long thought to be solely a deleterious …

Neuroinflammation following traumatic brain injury: take it seriously or not

R Zheng, K Lee, Z Qi, Z Wang, Z Xu, X Wu… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …

Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention

A Kumar, DJ Loane - Brain, behavior, and immunity, 2012 - Elsevier
Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities

D Lozano, GS Gonzales-Portillo, S Acosta… - Neuropsychiatric …, 2015 - Taylor & Francis
Traumatic brain injury (TBI) is a serious public health problem accounting for 1.4 million
emergency room visits by US citizens each year. Although TBI has been traditionally …

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …

Bridge between neuroimmunity and traumatic brain injury

ML Kelso, HE Gendelman - Current pharmaceutical design, 2014 - ingentaconnect.com
The pathophysiology of degenerative, infectious, inflammatory and traumatic diseases of the
central nervous system includes a significant immune component. As to the latter, damage to …

Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities

Y Xiong, A Mahmood, M Chopp - Chinese Journal of Traumatology, 2018 - mednexus.org
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide.
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …

New perspectives on central and peripheral immune responses to acute traumatic brain injury

M Das, S Mohapatra, SS Mohapatra - Journal of neuroinflammation, 2012 - Springer
Traumatic injury to the brain (TBI) results in a complex set of responses involving various
symptoms and long-term consequences. TBI of any form can cause cognitive, behavioral …