During development and throughout life, a variety of specialized cells must be generated to
ensure the proper function of each tissue and organ. Chromatin plays a key role in …

Differences in chromatin organization are key to the multiplicity of cell states that arise from a
single genetic background, yet the landscapes of in vivo tissues remain largely uncharted …

Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it
provides a unique assay to study the interplay between transcription factors and chromatin …

Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

Embryonic stem cells have an unlimited potential for self‐renewal yet are pluripotent,
capable of differentiating into three different germ layers and ultimately into multiple cell …

Pluripotent stem cells give rise to all cells of the adult organism, making them an invaluable
tool in regenerative medicine. In response to differentiation cues, they can activate markedly …

The fusion of the gametes upon fertilization results in the formation of a totipotent cell.
Embryonic chromatin is expected to be able to support a large degree of plasticity. However …

Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types,
but it is unclear how global epigenetic changes are regulated during this process. Here, we …

The pluripotent state of embryonic stem cells is maintained by a core network of transcription
factors, and by chromatin remodelling factors that support an environment permissive for …