PROTACs in gastrointestinal cancers

Y Chen, Q Yang, J Xu, L Tang, Y Zhang, F Du… - Molecular Therapy …, 2022 - cell.com
Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …

Proteolysis-targeting chimeras (PROTACs) in cancer therapy

X Li, W Pu, Q Zheng, M Ai, S Chen, Y Peng - Molecular cancer, 2022 - Springer
Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein
degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits …

Small-molecule PROTACs: novel agents for cancer therapy

Y Wan, C Yan, H Gao, T Liu - Future medicinal chemistry, 2020 - Taylor & Francis
Proteolysis-targeting chimera (PROTAC) is a new technology to selectively degrade target
proteins via ubiquitin-proteasome system. PROTAC molecules (PROTACs) are a class of …

Proteolysis-targeting chimeras: a promising technique in cancer therapy for gaining insights into tumor development

M Lv, W Hu, S Zhang, L He, C Hu, S Yang - Cancer Letters, 2022 - Elsevier
Proteolysis-targeting chimeras (PROTACs) are small molecules that specifically link E3
ubiquitin ligases to proteins of interest to mediate targeted ubiquitination and degradation …

PROTAC: A promising technology for cancer treatment

X Zhou, R Dong, JY Zhang, X Zheng, LP Sun - European journal of …, 2020 - Elsevier
Proteolysis-targeting chimeric molecules (PROTACs), which attract much more attention
today, may be a potential way to treat cancer. PROTACs are made up of ligands of target …

Target protein degradation by protacs: A budding cancer treatment strategy

D Choudhary, A Kaur, P Singh, G Chaudhary… - Pharmacology & …, 2023 - Elsevier
Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …

New-generation advanced PROTACs as potential therapeutic agents in cancer therapy

C Wang, Y Zhang, W Chen, Y Wu, D Xing - Molecular Cancer, 2024 - Springer
Proteolysis-targeting chimeras (PROTACs) technology has garnered significant attention
over the last 10 years, representing a burgeoning therapeutic approach with the potential to …

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

X Li, Y Song - Journal of hematology & oncology, 2020 - Springer
Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for
targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly …

PROTACs: current trends in protein degradation by proteolysis-targeting chimeras

J Madan, VK Ahuja, K Dua, S Samajdar… - BioDrugs, 2022 - Springer
In the recent past, proteolysis-targeting chimera (PROTAC) technology has received
enormous attention for its ability to overcome the limitations of protein inhibitors and its …

Proteolysis-targeting chimeras (PROTACs) in cancer therapy: present and future

R Li, M Liu, Z Yang, J Li, Y Gao, R Tan - Molecules, 2022 - mdpi.com
The PROteolysis TArgeting Chimeras (PROTACs) is an innovative technique for the
selective degradation of target proteins via the ubiquitin–proteasome system. Compared …