This thesis documents characterization of mice (MHC-ODC mice) with cardiac specific
expression of a stable ornithine decarboxylase (ODC), a rate-controlling enzyme in the …

Ornithine decarboxylase (ODC), the first enzyme of polyamine metabolism, is rapidly
upregulated in response to agents that induce a pathological cardiac hypertrophy …

Ornithine decarboxylase (ODC), the first enzyme of polyamine metabolism, is rapidly
upregulated in response to agents that induce a pathological cardiac hypertrophy …

Cardiac muscle hypertrophy is one of the most important compensatory responses of the
heart to multiple stresses that may be placed on it. If the stress is not relieved, sustained …

Both ornithine decarboxylase (ODC) and nitric oxide synthase (NOS) activities rely on the
availability of the common substrate L-arginine, which is directly processed by NOS to nitric …

These studies were designed to determine the consequences of constitutive overexpression
of ornithine decarboxylase (ODC) in the heart. Induction of ODC is known to occur in …

The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in
polyamine biosynthesis, by beta‐adrenergic agents may have in heart hypertrophy is a …

Two lines of transgenic mice were produced with constitutive expression of antizyme-1 in the
heart, driven from the cardiac α-myosin heavy chain promoter. The use of engineered …

Polyamines are thought to play an essential role in cellular hypertrophy and proliferation.
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in …

The role of ornithine decarboxylase (ODC) in polyamine metabolism has long been
established, but the exact source of ornithine has always been unclear. The arginase …