Cardiac ischaemia and reperfusion leads to irreversible injury and subsequent tissue
remodelling. Initial reperfusion seems to shift arginine metabolism from nitric oxide (NO) to …

Induction and activation of arginase is among the fastest responses of the heart to ischemic
events. Induction of arginase expression and enzyme activation under ischemic conditions …

Aim Ischaemia–reperfusion injury is associated with reduced bioavailability of nitric oxide
(NO) and microvascular dysfunction. One emerging mechanism behind reduced NO …

Consumption of L-arginine contributes to reduced bioavailability of nitric oxide (NO) that is
critical for the development of ischemia-reperfusion injury. The aim of the study was to …

BACKGROUND: Studies in myocardial ischemia and reperfusion have demonstrated
damage to endothelium, impaired production and release of vasoactive substances such as …

Myocardial ischaemia followed by reperfusion (I/R) is associated with impaired endothelial
function including diminished release and/or effects of nitric oxide (NO) which may …

The flux of arginine after ischemia-reperfusion in the rat kidney. Background Renal arginine
synthesis is regulated by arginine plasma levels. The amino acid arginine is synthesized in …

Aims Nitric oxide (NO) is vital for the integrity of the cardiovascular system and protection
against ischaemic heart disease. Arginase is up-regulated during ischaemia–reperfusion …

Reduced bioavailability of nitric oxide (NO) contributes to the development of myocardial
ischemia-reperfusion (I/R) injury. Increased activity of arginase is a potential factor that …

The effects of L-arginine on ischemia/reperfusion-induced myocardial dysfunction as well as
the tissue activity of nitric oxide synthase (NOS) were investigated in rat isolated Langendorff …