Within the cell nucleus, the organization of the eukaryotic DNA into chromatin uses histones
as components of its building block, the nucleosome. This chromatin organization …

Histones are fundamental structural components of chromatin. Eukaryotic DNA is wound
around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 …

Histones are a major component of chromatin, the nucleoprotein complex fundamental to
regulating transcription, facilitating cell division, and maintaining genome integrity in almost …

Chromatin organization in the nucleus provides a vast repertoire of information in addition to
that encoded genetically. Understanding how this organization impacts genome stability and …

Histone proteins wrap around DNA to form nucleosomes, which further compact into the
higher-order structure of chromatin. In addition to the canonical histones, there are also …

Histone variants, which generally differ in few amino acid residues, can replace core
histones (H1, H2A, H2B, and H3) to confer specific structural and functional features to …

In eukaryotes, DNA is packaged into chromatin by canonical histone proteins. The
specialized histone H3 variant CENP-A provides an epigenetic and structural basis for …

Within the nucleus, the interplay between lineage-specific transcription factors and
chromatin dynamics defines cellular identity. Control of this interplay is necessary to properly …

Most histones are assembled into nucleosomes during replication to package genomic
DNA. However, several variant histones are deposited independently of replication at …

Histone variants are an important part of the histone contribution to chromatin epigenetics. In
this review, we describe how the known structural differences of these variants from their …