Clonal hematopoiesis (CH) is an entity hallmarked by skewed hematopoiesis with persistent
overrepresentation of cells from a common stem/progenitor lineage harboring single …

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Abstract Clonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic
clones—can differ in frequency and cellular fitness by CH type (eg, mutations in driver genes …

Abstract Purpose of Review Clonal hematopoiesis (CH) is an age-dependent process
detectable using advanced sequencing technologies and is associated with multiple …

Unlike other forms of somatic mosaicism such as cancer, CH is a premalignant state that
becomes a nearubiquitous phenomenon with advanced age. Because this condition is not …

Hematopoietic stem cells (HSCs) are polyfunctional, regenerating all blood cells via
hematopoiesis throughout life. Clonal hematopoiesis (CH) is said to occur when a …

Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs)
acquire mutations that confer a fitness advantage and clonally expand in a process now …

Clonal hematopoiesis (CH) is common in older persons and is associated with an increased
risk of hematologic cancer. Here, we review studies establishing an association between CH …

The study of somatic mutations and the associated clonal mosaicism across the human body
has transformed our understanding of aging and its links to cancer. In proliferative human …