RNA is a versatile biological macromolecule that is crucial in mobilizing and interpreting our
genetic information. It is not surprising then that researchers have sought to exploit the …

The study of RNA has continually emphasized the structural and functional versatility of RNA
molecules. This versatility has inspired translational and clinical researchers to explore the …

A recent revolution in RNA biology has led to the identification of new RNA classes with
unanticipated functions, new types of RNA modifications, an unexpected multiplicity of …

Ribonucleic acid (RNA) therapeutics are being actively researched as a therapeutic
modality in preclinical and clinical studies. They have become one of the most ubiquitously …

Small-molecule and protein/antibody drugs mainly act on genome-derived proteins to exert
pharmacological effects. RNA based therapies hold the promise to expand the range of …

The concepts of developing RNAs as new molecular entities for therapies have arisen again
and again since the discoveries of antisense RNAs, direct RNA-protein interactions …

RNA therapy refers to the treatment or prevention of diseases using RNA-based molecules.
The recent advent of a series of effective messenger RNA-based vaccines in response to the …

The knowledge about non-coding RNAs (ncRNAs) is rapidly increasing with new data
continuously emerging, regarding their diverse types, applications, and roles. Particular …

Recent advances in the generation, purification and cellular delivery of RNA have enabled
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …

RNA duplexes of 21–23 nucleotides (nts), with~ 2 nt 3'overhangs (called small interfering
RNAs or siRNAs), have recently been shown to mediate sequence-specific inhibition of …