Molecular basis for inhibiting human glucose transporters by exofacial inhibitors
Human glucose transporters (GLUTs) are responsible for cellular uptake of hexoses.
Elevated expression of GLUTs, particularly GLUT1 and GLUT3, is required to fuel the …
Elevated expression of GLUTs, particularly GLUT1 and GLUT3, is required to fuel the …
GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems
The passive transport of glucose and related hexoses in human cells is facilitated by
members of the glucose transporter family (GLUT, SLC2 gene family). GLUT3 is a high …
members of the glucose transporter family (GLUT, SLC2 gene family). GLUT3 is a high …
Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems
Glucose is an essential energy source for cells. In humans, its passive diffusion through the
cell membrane is facilitated by members of the glucose transporter family (GLUT, SLC2 …
cell membrane is facilitated by members of the glucose transporter family (GLUT, SLC2 …
[HTML][HTML] Functional expression of the human glucose transporters GLUT2 and GLUT3 in yeast offers novel screening systems for GLUT-targeting drugs
S Schmidl, SA Tamayo Rojas, CV Iancu… - Frontiers in molecular …, 2021 - frontiersin.org
Human GLUT2 and GLUT3, members of the GLUT/SLC2 gene family, facilitate glucose
transport in specific tissues. Their malfunction or misregulation is associated with serious …
transport in specific tissues. Their malfunction or misregulation is associated with serious …
Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation
AM George Thompson, O Ursu, P Babkin, CV Iancu… - Scientific reports, 2016 - nature.com
GLUT5, a fructose-transporting member of the facilitative glucose transporter (GLUT, SLC2)
family, is a therapeutic target for diabetes and cancer but has no potent inhibitors. We …
family, is a therapeutic target for diabetes and cancer but has no potent inhibitors. We …
In silico modeling-based identification of glucose transporter 4 (GLUT4)-selective inhibitors for cancer therapy
Tumor cells rely on elevated glucose consumption and metabolism for survival and
proliferation. Glucose transporters mediating glucose entry are key proximal rate-limiting …
proliferation. Glucose transporters mediating glucose entry are key proximal rate-limiting …
Synthesis of Indomorphan pseudo‐natural product inhibitors of glucose transporters GLUT‐1 and‐3
J Ceballos, M Schwalfenberg… - Angewandte …, 2019 - Wiley Online Library
Bioactive compound design based on natural product (NP) structure may be limited because
of partial coverage of NP‐like chemical space and biological target space. These limitations …
of partial coverage of NP‐like chemical space and biological target space. These limitations …
GLUT1 biological function and inhibition: research advances
S Cao, Y Chen, Y Ren, Y Feng… - Future Medicinal Chemistry, 2021 - Future Science
The GLUT is a key regulator of glucose metabolism and is widely expressed on the surface
of most cells of the body. GLUT provides a variety of nutrients for the growth, proliferation …
of most cells of the body. GLUT provides a variety of nutrients for the growth, proliferation …
Glucose transporter 4: Insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression
The glucose transporter family (GLUT) consists of fourteen members. It is responsible for
glucose homeostasis and glucose transport from the extracellular space to the cell …
glucose homeostasis and glucose transport from the extracellular space to the cell …
Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs
Dear Editor, Glucose is the primary energy supply for metabolism and a versatile precursor
for biomolecule synthesis. Cellular uptake of glucose mainly relies on two types of glucose …
for biomolecule synthesis. Cellular uptake of glucose mainly relies on two types of glucose …