Neuraminidase inhibitors modulate infections that involve sialic acids, making quantitative
analyses of this inhibitory effect important for selecting and designing potential therapeutics …

Background Enzyme inhibitors comprise the largest class of pharmaceutical compounds.
The discovery and development of new enzyme inhibitor drug candidates depends on …

Phospholipid nanogels enhance the stability and performance of the exoglycosidase
enzyme neuraminidase and are used to create a fixed zone of enzyme within a capillary …

Capillary electrophoresis with laser induced fluorescence detection (CE-LIF) was employed
for rapid sialic acid speciation, facilitating the quantitative determination of N …

An example of application of in-capillary derivatization for CE, obtained by using the
throughout-capillary format, is presented. Introduction of a sialoglycan (N …

This review focuses on the methods and current trends in determination of neuraminidases
(NAs) activity and evaluation of neuraminidase inhibitors (NAIs) by means of biochemical …

Toyopearl 650 M was purchased from Tosoh (Japan). The 10-~ 1 pipette tips with filter (cat.
no. FI08-96R-I0) and thin-well 0.2-ml PCR microtubes (cat. no. 430-01XNBZ-Q) with caps …

Sialylation and sialic acid linkage in N-glycans are markers of disease but are analytically
challenging to quantify. A capillary electrophoresis method is reported that integrates a …

An electrophoretically mediated microanalysis (EMMA) method for screening neuraminidase
inhibitors in depolymerized glycosaminoglycan and natural extracts is described. In the …

A simple and highly sensitive capillary electrophoresis (CE) method for determining the
content of N‐acetylneuraminic acid (Neu5Ac) in glycoproteins was developed. Neu5Ac was …