AIM OF THE STUDY: Smooth muscle cells build up the normal media and stabilize
atherosclerotic lesions whereas an inflammatory component is determinant for unstable …

BACKGROUND: Studies in humans and mice using the expression of an X-linked gene or
lineage tracing, respectively, have suggested that clones of smooth muscle cells (SMCs) …

Background and aims Despite the clinical importance of atherosclerosis, the origin of cells
within atherosclerotic plaques is not fully understood. Due to the lack of a definitive lineage …

Objectives—Characterize the phenotypic features of media and intima coronary artery
smooth muscle cells (SMCs) in mildly stenotic plaques, erosions, stable plaques, and in …

BACKGROUND Atherosclerotic plaques are heterogeneous vascular lesions. Changes in
cell plaque composition are fundamental events inside the plaque microenvironment that …

Unstable angina and myocardial infarction are the clinical manifestations of the abrupt
thrombotic occlusion of an epicardial coronary artery as a result of spontaneous …

OBJECTIVES To determine the phenotypical state of smooth muscle cells during the
pathogenesis of an atherosclerotic lesion, and to determine the morphological state of the …

The atherosclerotic mouse aorta consists of a heterogeneous population of cells, including
macrophages, endothelial cells, and smooth muscle cells that play critical roles in …

The internal mammary artery (IMA) is used widely in bypass grafting for coronary artery
disease because of its resistance to atherosclerotic obstruction. Since there are no data on …

The origin of intimal smooth muscle cells in native atherosclerosis, post-injury neointima
formation, allograft vasculopathy, and vein graft atherosclerosis has been the subject of a …