Background: Survival and integrity of the spiral ganglion is vital for hearing in background
noise and for optimal functioning of cochlear implants. Numerous studies have …

The intracochlear infusion of neurotrophic factors via a mini-osmotic pump has been shown
to prevent deafness-induced spiral ganglion neuron (SGN) degeneration; however, the use …

The cochlear implant provides auditory cues to profoundly deaf patients by electrically
stimulating the residual spiral ganglion neurons. These neurons, however, undergo …

Gene therapy has been investigated as a way to introduce a variety of genes to treat
neurological disorders. An important clinical consideration is its long-term effectiveness. This …

Hearing impairment is a major health and economic concern worldwide. Currently, the
cochlear implant (CI) is the standard of care for remediation of severe to profound hearing …

Spiral ganglion neurons (SGNs), the target cells of the cochlear implant, undergo gradual
degeneration following loss of the sensory epithelium in deafness. The preservation of a …

A cochlear implant can restore hearing function by electrically exciting spiral ganglion
neurons (SGNs) in the deaf cochlea. However, following deafness SGNs undergo …

Cochlear implantation is a highly successful intervention for the treatment of deafness that
depends on electrical stimulation of the inner ear's surviving spiral ganglion neurons. It is …

Sensorineural hearing loss is a common disability, but treatment options are currently limited
to cochlear implants and hearing aids. Studies are therefore being conducted to provide …

A cochlear implant may be used to electrically stimulate spiral ganglion neurons (SGNs) in
people with severe sensorineural hearing loss (SNHL). However, these neurons …