Improving control of gene therapy-based Neurotrophin delivery for inner ear applications
M St. Peter, DE Brough, A Lawrence… - … in Bioengineering and …, 2022 - frontiersin.org
Background: Survival and integrity of the spiral ganglion is vital for hearing in background
noise and for optimal functioning of cochlear implants. Numerous studies have …
noise and for optimal functioning of cochlear implants. Numerous studies have …
Schwann cells genetically modified to express neurotrophins promote spiral ganglion neuron survival in vitro
LN Pettingill, RL Minter, RK Shepherd - Neuroscience, 2008 - Elsevier
The intracochlear infusion of neurotrophic factors via a mini-osmotic pump has been shown
to prevent deafness-induced spiral ganglion neuron (SGN) degeneration; however, the use …
to prevent deafness-induced spiral ganglion neuron (SGN) degeneration; however, the use …
Neurotrophin gene therapy for sustained neural preservation after deafness
The cochlear implant provides auditory cues to profoundly deaf patients by electrically
stimulating the residual spiral ganglion neurons. These neurons, however, undergo …
stimulating the residual spiral ganglion neurons. These neurons, however, undergo …
Viability of long-term gene therapy in the cochlea
Gene therapy has been investigated as a way to introduce a variety of genes to treat
neurological disorders. An important clinical consideration is its long-term effectiveness. This …
neurological disorders. An important clinical consideration is its long-term effectiveness. This …
Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness
PA Leake, O Akil, H Lang - Hearing research, 2020 - Elsevier
Hearing impairment is a major health and economic concern worldwide. Currently, the
cochlear implant (CI) is the standard of care for remediation of severe to profound hearing …
cochlear implant (CI) is the standard of care for remediation of severe to profound hearing …
Development of a cell-based treatment for long-term neurotrophin expression and spiral ganglion neuron survival
MP Zanin, M Hellström, RK Shepherd, AR Harvey… - Neuroscience, 2014 - Elsevier
Spiral ganglion neurons (SGNs), the target cells of the cochlear implant, undergo gradual
degeneration following loss of the sensory epithelium in deafness. The preservation of a …
degeneration following loss of the sensory epithelium in deafness. The preservation of a …
The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection
AK Wise, T Tu, PJ Atkinson, BO Flynn, BE Sgro… - Hearing research, 2011 - Elsevier
A cochlear implant can restore hearing function by electrically exciting spiral ganglion
neurons (SGNs) in the deaf cochlea. However, following deafness SGNs undergo …
neurons (SGNs) in the deaf cochlea. However, following deafness SGNs undergo …
Neurotrophin therapy and cochlear implantation: translating animal models to human therapy
H Staecker, C Garnham - Experimental neurology, 2010 - Elsevier
Cochlear implantation is a highly successful intervention for the treatment of deafness that
depends on electrical stimulation of the inner ear's surviving spiral ganglion neurons. It is …
depends on electrical stimulation of the inner ear's surviving spiral ganglion neurons. It is …
Cell–gene delivery of brain-derived neurotrophic factor to the mouse inner ear
T Okano, T Nakagawa, T Kita, T Endo, J Ito - Molecular Therapy, 2006 - cell.com
Sensorineural hearing loss is a common disability, but treatment options are currently limited
to cochlear implants and hearing aids. Studies are therefore being conducted to provide …
to cochlear implants and hearing aids. Studies are therefore being conducted to provide …
Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea
AK Wise, CR Hume, BO Flynn, YS Jeelall, CL Suhr… - Molecular Therapy, 2010 - cell.com
A cochlear implant may be used to electrically stimulate spiral ganglion neurons (SGNs) in
people with severe sensorineural hearing loss (SNHL). However, these neurons …
people with severe sensorineural hearing loss (SNHL). However, these neurons …