Damage to the axonal white matter tracts within the brain is a key cause of neurological
impairment and long-term disability following traumatic brain injury (TBI). Understanding …

Traumatic brain injury (TBI) resulting in poor neurological outcome is predominantly
associated with diffuse brain damage and secondary hypoxic insults. Post-traumatic hypoxia …

Background The combination of diffuse brain injury with a hypoxic insult is associated with
poor outcomes in patients with traumatic brain injury. In this study, we investigated the …

Over 2.8 million people experience mild traumatic brain injury (TBI) in the United States
each year, which may lead to long‐term neurological dysfunction. The mechanical forces …

Axonal injury (AI), one of the principal determinants of clinical outcome after head injury,
may evolve over several hours after injury, raising the future possibility of therapeutic …

Background While it is understood that raised intracranial pressure (ICP) after traumatic
brain injury (TBI) may negatively impact on brain tissue oxygenation (P bt O 2), few studies …

This study examined the effect of posttraumatic hypoxia on cerebral vascular responsivity
and axonal damage, while also exploring hypothermia's potential to attenuate these …

Traumatic brain injury (TBI) in animals and man generates widespread axonal injury
characterized by focal axolemmal permeability changes, induction of calpain-mediated …

Pulmonary dysfunction leading to secondary hypoxia is a common complication of spinal
cord injury (SCI). The purpose of this study was to clarify the behavioral and …

Hypoxemia immediately following traumatic brain injury (TBI) has been observed to
exacerbate injury. However, it remains unclear whether delayed hypoxemia beyond the …