N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition
N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase primarily
found in the endosomal–lysosomal compartment of innate and adaptive immune cells …
found in the endosomal–lysosomal compartment of innate and adaptive immune cells …
A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation
A Ribeiro, S Pontis, L Mengatto, A Armirotti… - ACS chemical …, 2015 - ACS Publications
Fatty acid ethanolamides such as palmitoylethanolamide (PEA) and oleoylethanolamide
(OEA) are lipid-derived mediators that potently inhibit pain and inflammation by ligating type …
(OEA) are lipid-derived mediators that potently inhibit pain and inflammation by ligating type …
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
C Solorzano, C Zhu, N Battista… - Proceedings of the …, 2009 - National Acad Sciences
Identifying points of control in inflammation is essential to discovering safe and effective
antiinflammatory medicines. Palmitoylethanolamide (PEA) is a naturally occurring lipid …
antiinflammatory medicines. Palmitoylethanolamide (PEA) is a naturally occurring lipid …
Molecular mechanism of activation of the immunoregulatory amidase NAAA
Palmitoylethanolamide is a bioactive lipid that strongly alleviates pain and inflammation in
animal models and in humans. Its signaling activity is terminated through degradation by N …
animal models and in humans. Its signaling activity is terminated through degradation by N …
Advances in the discovery of N-acylethanolamine acid amidase inhibitors
T Bandiera, S Ponzano, D Piomelli - Pharmacological research, 2014 - Elsevier
N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that hydrolyzes saturated
or monounsaturated fatty acid ethanolamides, such as palmitoylethanolamide (PEA) and …
or monounsaturated fatty acid ethanolamides, such as palmitoylethanolamide (PEA) and …
N-acylethanolamine hydrolyzing acid amidase inhibition: tools and potential therapeutic opportunities
P Bottemanne, GG Muccioli, M Alhouayek - Drug discovery today, 2018 - Elsevier
Highlights•NAAA is a key enzyme controlling the levels of bioactive N-acylethanolamines.•
Novel, systemically active inhibitors are now available to study NAAA roles in vivo.•NAAA …
Novel, systemically active inhibitors are now available to study NAAA roles in vivo.•NAAA …
Synthesis and Structure−Activity Relationships of N-(2-Oxo-3-oxetanyl)amides as N-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors
C Solorzano, F Antonietti, A Duranti… - Journal of medicinal …, 2010 - ACS Publications
The fatty acid ethanolamides (FAEs) are a family of bioactive lipid mediators that include the
endogenous agonist of peroxisome proliferator-activated receptor-α, palmitoylethanolamide …
endogenous agonist of peroxisome proliferator-activated receptor-α, palmitoylethanolamide …
[HTML][HTML] Design and Synthesis of Potent N-Acylethanolamine-hydrolyzing Acid Amidase (NAAA) Inhibitor as Anti-Inflammatory Compounds
N-acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme involved in
biological deactivation of N-palmitoylethanolamide (PEA), which exerts anti-inflammatory …
biological deactivation of N-palmitoylethanolamide (PEA), which exerts anti-inflammatory …
Harnessing the anti-inflammatory potential of palmitoylethanolamide
M Alhouayek, GG Muccioli - Drug Discovery Today, 2014 - Elsevier
Highlights•PEA is an anti-inflammatory and neuroprotective compound.•Pharmacological
tools are available to control PEA levels via FAAH and NAAA inhibition.•FAAH and NAAA …
tools are available to control PEA levels via FAAH and NAAA inhibition.•FAAH and NAAA …
Synthesis and Structure–Activity Relationship (SAR) of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters, a Class of Potent N-Acylethanolamine Acid Amidase (NAAA) …
S Ponzano, F Bertozzi, L Mengatto… - Journal of medicinal …, 2013 - ACS Publications
N-Acylethanolamine acid amidase (NAAA) is a lysosomal cysteine hydrolase involved in the
degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of …
degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of …