N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase primarily
found in the endosomal–lysosomal compartment of innate and adaptive immune cells …

Fatty acid ethanolamides such as palmitoylethanolamide (PEA) and oleoylethanolamide
(OEA) are lipid-derived mediators that potently inhibit pain and inflammation by ligating type …

Identifying points of control in inflammation is essential to discovering safe and effective
antiinflammatory medicines. Palmitoylethanolamide (PEA) is a naturally occurring lipid …

Palmitoylethanolamide is a bioactive lipid that strongly alleviates pain and inflammation in
animal models and in humans. Its signaling activity is terminated through degradation by N …

N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that hydrolyzes saturated
or monounsaturated fatty acid ethanolamides, such as palmitoylethanolamide (PEA) and …

Highlights•NAAA is a key enzyme controlling the levels of bioactive N-acylethanolamines.•
Novel, systemically active inhibitors are now available to study NAAA roles in vivo.•NAAA …

The fatty acid ethanolamides (FAEs) are a family of bioactive lipid mediators that include the
endogenous agonist of peroxisome proliferator-activated receptor-α, palmitoylethanolamide …

N-acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme involved in
biological deactivation of N-palmitoylethanolamide (PEA), which exerts anti-inflammatory …

Highlights•PEA is an anti-inflammatory and neuroprotective compound.•Pharmacological
tools are available to control PEA levels via FAAH and NAAA inhibition.•FAAH and NAAA …

N-Acylethanolamine acid amidase (NAAA) is a lysosomal cysteine hydrolase involved in the
degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of …