The intestinal mucosa contains the largest population of antibody-secreting plasma cells in
the body, and in humans several grams of secretory immunoglobulin A (SIgA) are released …

Secretory IgA has long been a divisive molecule. Some immunologists point to the mild
phenotype of IgA deficiency to justify ignoring it, while some consider its abundance and …

Highlights•Secretory immunoglobulin A (SIgA) is the dominant antibody at mucosal
surfaces.•Gut commensals are coated by SIgA at varied levels.•SIgA targeting regulates …

In the gastrointestinal tract (GIT), the immune system interacts with a variety of
microorganisms, including pathogens as well as beneficial symbionts that perform important …

Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions. The majority of
plasma cells producing IgA are located within mucosal membranes lining the intestines …

Abstract Secretory IgA (SIgA) serves as the first line of defense in protecting the intestinal
epithelium from enteric toxins and pathogenic microorganisms. Through a process known as …

Immunoglobulin A is the main element of the humoral immune response that has been
selected through evolution, together with innate mucosal defences, to provide protection …

Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In
this review, we summarize recent advances in our understanding of the sites, mechanisms …

Gut microbiota has extensive and tremendous impacts on human physiology and pathology.
The regulation of microbiota is therefore a cardinal problem for the mutualistic relationship …

Abstract Secretory IgA (SIgA) antibodies in the intestinal tract form the first line of antigen-
specific immune defense, preventing access of pathogens as well as commensal microbes …