Function and therapeutic potential of N-acyl amino acids

SA Prakash, RK Kamlekar - Chemistry and physics of lipids, 2021 - Elsevier
N-acyl amino acids (NAAs) are amphiphilic molecules, with different potential fatty acid and
head group moieties. NAAs are the largest family of anandamide congener lipids discovered …

N‐Acyl amino acids and N‐acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets

M Connor, CW Vaughan… - British journal of …, 2010 - Wiley Online Library
The myriad functions of lipids as signalling molecules is one of the most interesting fields in
contemporary pharmacology, with a host of compounds recognized as mediators of …

N-acyl amino acids (elmiric acids): endogenous signaling molecules with therapeutic potential

SH Burstein - Molecular pharmacology, 2018 - ASPET
The subject of N-acyl amino acid conjugates has been rapidly growing in recent years,
especially with regard to their analgesic and anti-inflammatory actions. The field comprises a …

Novel endogenous N‐acyl glycines: identification and characterization

HB Bradshaw, N Rimmerman, SSJ Hu, S Burstein… - Vitamins & …, 2009 - Elsevier
Discovery of the endogenous cannabinoid and N‐acyl amide, anandamide (N‐arachidonoyl
ethanolamine), paved the way for lipidomics discoveries in the growing family of N‐acyl …

Anandamide revisited: how cholesterol and ceramides control receptor-dependent and receptor-independent signal transmission pathways of a lipid neurotransmitter

CD Scala, J Fantini, N Yahi, FJ Barrantes, H Chahinian - Biomolecules, 2018 - mdpi.com
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated
fatty acid. The chemical differences between anandamide and arachidonic acid result in a …

N-Acyl Amino Acids: Metabolism, Molecular Targets, and Role in Biological Processes

N Battista, M Bari, T Bisogno - Biomolecules, 2019 - mdpi.com
The lipid signal is becoming increasingly crowded as increasingly fatty acid amide
derivatives are being identified and considered relevant therapeutic targets. The …

The Biosynthesis and Metabolism of the N-Acylated Aromatic Amino Acids: N-Acylphenylalanine, N-Acyltyrosine, N-Acyltryptophan, and N-Acylhistidine

S Bhandari, KS Bisht, DJ Merkler - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
The fatty acid amides are a family of lipids composed of two chemical moieties, a fatty acid
and a biogenic amine linked together in an amide bond. This lipid family is structurally …

[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Metabolism, physiology, and analyses of primary fatty acid amides

EB Divito, M Cascio - Chemical reviews, 2013 - ACS Publications
Primary fatty acid amides (PFAMs) are a group of lipids that has been identified as bioactive
lipid signaling molecules. In this review we discuss the progress in identifying metabolism …

Biosynthesis, degradation and pharmacological importance of the fatty acid amides

EK Farrell, DJ Merkler - Drug discovery today, 2008 - Elsevier
The identification of two biologically active fatty acid amides, N-arachidonoylethanolamine
(anandamide) and oleamide, has generated a great deal of excitement and stimulated …