Posterior semicircular canal approach for inner ear gene delivery in neonatal mouse

K Isgrig, WW Chien - JoVE (Journal of Visualized Experiments), 2018 - jove.com
Inner ear gene therapy offers great promise as a potential treatment for hearing loss and
dizziness. One of the critical determinants of the success of inner ear gene therapy is to find …

Surgical methods for inner ear gene delivery in neonatal mouse

K Isgrig, WW Chien - Viral Vectors for Gene Therapy: Methods and …, 2019 - Springer
Inner ear gene therapy offers great potential as a treatment for hearing loss and dizziness.
The surgical method used to deliver gene therapy into the inner ear is a critical step in …

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

J Zhu, JW Choi, Y Ishibashi, K Isgrig, M Grati… - Scientific reports, 2021 - nature.com
Hearing loss is a common disability affecting the world's population today. While several
studies have shown that inner ear gene therapy can be successfully applied to mouse …

Canalostomy is an ideal surgery route for inner ear gene delivery in big animal model

XJ Ji, W Chen, X Wang, Y Zhang, Q Liu… - Acta Oto …, 2019 - Taylor & Francis
Background: Inner gene therapy offers great promises as a potential treatment for hearing
loss. Aims/objectives: One of the critical determinants of the success of inner ear gene …

Inner ear gene delivery: vectors and routes

C Valentini, B Szeto, JW Kysar… - Hearing, balance and …, 2020 - Taylor & Francis
Objectives Current treatments for hearing loss offer some functional improvements in
hearing, but do not restore normal hearing. The aim of this review is to highlight recent …

Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane

O Akil, SL Rouse, DK Chan, LR Lustig - JoVE (Journal of Visualized …, 2015 - jove.com
Gene therapy, used to achieve functional recovery from sensorineural deafness, promises to
grant better understanding of the underlying molecular and genetic mechanisms that …

Current status and prospects of gene therapy for the inner ear

H Sun, A Huang, S Cao - Human gene therapy, 2011 - liebertpub.com
Inner ear diseases are common and often result in hearing disability. Sensorineural hearing
loss is the main cause of hearing disability. So far, no effective treatment is available …

Practical aspects of inner ear gene delivery for research and clinical applications

S Lee, A Dondzillo, SP Gubbels, Y Raphael - Hearing research, 2020 - Elsevier
The application of gene therapy is widely expanding in research and continuously improving
in preparation for clinical applications. The inner ear is an attractive target for gene therapy …

Gene transfer in inner ear cells: a challenging race

R Sacheli, L Delacroix, P Vandenackerveken… - Gene therapy, 2013 - nature.com
Recent advances in human genomics led to the identification of numerous defective genes
causing deafness, which represent novel putative therapeutic targets. Future gene-based …

The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in mice

K Kawamoto, SH Oh, S Kanzaki, N Brown, Y Raphael - Molecular Therapy, 2001 - cell.com
Mice present an ideal model for inner ear gene therapy because their genome is being
rapidly sequenced, their generation time is relatively short, and they serve as a valuable …