Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-
cochlear barrier exists, similar physiologically to the blood-brain barrier, which limits the …

Numerous disease processes cause inner ear dysfunction and represent an opportunity for
therapeutic intervention. Hearing loss is the common endpoint of many inner ear disorders …

For many years, drug delivery to the inner ear has been a challenge to physicians in the
treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has …

Hearing aids or cochlear implants constitute almost exclusively the treatment options
currently available to patients suffering from sensorineural hearing loss and related …

Effective and safe treatment of auditory and vestibular diseases has become increasingly
dependent on inner ear drug delivery systems. This review highlights recent advances in …

Inner ear diseases are not adequately treated by systemic drug administration mainly
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …

Optimal methods of inner ear drug delivery will depend on toxicity, therapeutic dose range,
and characteristics of the agent to be delivered. Advanced therapy development will likely …

Drug delivery to the inner ear is an ideal method to treat a wide variety of otologic conditions.
A broad range of potential applications is just beginning to be explored. New approaches …

Drug delivery to the ear is used to treat conditions of the middle and inner ear such as acute
and chronic otitis media, Ménière's disease, sensorineural hearing loss and tinnitus. Drugs …

Neurotology disorders such as vertigo, tinnitus, and hearing loss affect a significant
proportion of the population (estimated 39 million in the United States with moderate to …