Inflammatory molecular endotypes of nasal polyps derived from White and Japanese populations

T Nakayama, IT Lee, W Le, Y Tsunemi… - Journal of Allergy and …, 2022 - Elsevier
Background Emerging evidence suggests that chronic rhinosinusitis with nasal polyps
(CRSwNP) is a highly heterogeneous disease with disparate inflammatory characteristics …

Whole-transcriptome sequencing reveals heightened inflammation and defective host defence responses in chronic rhinosinusitis with nasal polyps

Y Peng, XX Zi, TF Tian, B Lee, J Lum… - European …, 2019 - Eur Respiratory Soc
Introduction The pathways underlying chronic rhinosinusitis with nasal polyps (CRSwNP)
are unclear. We conducted genome-wide gene expression analysis to determine pathways …

Distinct type 2-high inflammation associated molecular signatures of chronic rhinosinusitis with nasal polyps with comorbid asthma

M Wang, X Bu, G Luan, L Lin, Y Wang, J Jin… - Clinical and translational …, 2020 - Springer
Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid
asthma have more severe disease and are difficult to treat. However, the molecular …

Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non‐eosinophilic chronic rhinosinusitis

N Okada, T Nakayama, D Asaka… - … Forum of Allergy & …, 2018 - Wiley Online Library
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is known to have 2
phenotypes in East Asia. Eosinophilic CRSwNP (ECRSwNP), defined as tissue eosinophilia …

Transcriptome analysis reveals distinct gene expression profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps

W Wang, Z Gao, H Wang, T Li, W He, W Lv, J Zhang - Scientific Reports, 2016 - nature.com
Chronic rhinosinusitis with nasal polyps (CRSwNP), one of the most prevalent chronic
diseases, is characterized by persistent inflammation of sinonasal mucosa. However, the …

A family-based genome-wide association study of chronic rhinosinusitis with nasal polyps implicates several genes in the disease pathogenesis

A Bohman, J Juodakis, M Oscarsson, J Bacelis… - PLoS …, 2017 - journals.plos.org
Background The pathogenesis of chronic rhinosinusitis with nasal polyps is largely
unknown. Previous studies have given valuable information about genetic variants …

Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps

AI Klingler, WW Stevens, BK Tan, AT Peters… - Journal of Allergy and …, 2021 - Elsevier
Background Chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) is a common
disease that is characterized by multiple inflammatory endotypes. However, the molecular …

[HTML][HTML] Identification of inflammatory endotypes by clinical characteristics and nasal secretion biomarkers in chronic rhinosinusitis with nasal polyps

CL Guo, RY Lu, CS Wang, JF Zhao, L Pan… - … Archives of Allergy and …, 2023 - karger.com
Introduction: The emergency of biologics and surgical techniques targeting the specific
inflammatory endotype in chronic rhinosinusitis with nasal polyps (CRSwNP) asks for …

[PDF][PDF] Cellular phenotyping of chronic rhinosinusitis with nasal polyps

H Lou, Y Meng, Y Piao, N Zhang, C Bachert, C Wang… - Rhinology, 2016 - academia.edu
Background: Defining the phenotypes of chronic rhinosinusitis with nasal polyps (CRSwNP)
with prognosis may lead to delivery of personalized treatment. This study aimed to identify …

Chronic rhinosinusitis with nasal polyps in older adults: clinical presentation, pathophysiology, and comorbidity

WJ Song, JH Lee, HK Won, C Bachert - Current allergy and asthma reports, 2019 - Springer
Abstract Purpose of Review Chronic rhinosinusitis and nasal polyps (CRSwNP) is a
common condition that significantly affects patients' life. This work aims to provide an up-to …