Background Interactions between tumor cells and cells in the microenvironment contribute to
tumor development and metastasis. The spatial arrangement of individual cells in relation to …

Background Functional interactions between immune cells and neoplastic cells in the tumor
immune microenvironment have been actively pursued for both biomarker discovery for …

Emerging evidence suggests that not only the frequency and composition of tumor-
infiltrating leukocytes but also their spatial organization might be a major determinant of …

Head and neck squamous carcinoma (HNSCC) is highly infiltrated by immune cells,
including tumor-infiltrating lymphocytes and myeloid lineage cells. In the tumor …

The immune infiltration profiles of the tumor microenvironment have effects on the prognosis
of head and neck squamous cell carcinoma (HNSCC). Whereas, HNSCC is a …

Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumor
entities worldwide, with human papillomavirus (HPV) infection contributing to cancer …

Anti-PD1 antibody has been approved for metastatic squamous cell carcinoma of the head
and neck (SCCHN) and objective response rates of approximately 20% have been reported …

Introduction The importance of immune tumor microenvironment in the prognosis of patients
with head and neck squamous carcinomas (HNSCC) is increasingly recognized. We …

Background: Evaluating the tumor microenvironment and its influence on clinical
management and therapy response is becoming increasingly important. However, only a …

Head and neck squamous cell carcinomas (HNSCCs) belong to a group of diverse tumors,
which can be induced by infection with human papillomavirus (HPV) or tobacco and alcohol …