Uncertainty regarding which psychological mechanisms are fundamental in mediating SSRI
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Results gathered in the last 35 years clearly show that serotonin (5-HT) is involved in
anxiety. In agreement with this proposal, serotonin selective reuptake inhibitors (SSRIs) are …

Selective serotonin reuptake inhibitors (SSRIs) constitute a first-line antidepressant
intervention, though the precise cognitive and computational mechanisms that explain …

To make good decisions, humans need to learn about and integrate different sources of
appetitive and aversive information. While serotonin has been linked to value-based …

Abstract The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) affects numerous
behavioral and physiological processes. Drugs that alter 5-HT signaling treat several major …

Executive function entails the interplay of a group of cognitive processes enabling the
individual to anticipate consequences, attain self-control, and undertake appropriate goal …

HT1A receptors are widely expressed in the brain and play a critical role in feedback
inhibition of serotonin (5-HT) neurons through multiple mechanisms. Yet, it remains poorly …

5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of
emotional, cognitive and behavioural control processes. However, its precise contribution is …

Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a
novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are …