Background Molecular interrogation of genetic information has transformed our
understanding of disease and is now routinely integrated into the workup and monitoring of …

Several hematologic malignancies are associated with diverse genetic aberrations that
range from single base-pair substitution to complete chromosomal abnormalities. Before the …

The increasing knowledge on the pathogenesis of hematologic diseases has over the years
been translated into diagnostic and prognostic applications. Hematopathology and …

Once relegated to investigational or ancillary roles, nucleic acid-based molecular tests have
become essential for the diagnosis and management of most hematologic malignancies …

Abstract Purpose of Review Acute lymphoblastic leukemia (ALL) is a widely heterogeneous
disease in terms of genomic alterations, treatment options, and prognosis. While ALL is …

The field of diagnostic hematopathology is dynamic and evolving given the ongoing
accumulation of molecular information and demand for integration of this information into …

Rapidly evolving targeted and immunotherapies in non-small cell lung carcinoma (NSCLC)
have resulted in an enormous pressure to develop and implement laboratory assays that will …

Introduction Rapid technological advancements in clinical molecular genetics have
increased our diagnostic and prognostic capabilities in health care. Understanding these …

Hematopoietic disorders are often driven by genetic mutations and epigenetic alterations.
New advanced technologies including next-generation sequencing, ultra-deep PCR and …

Abstract Purpose of Review The usual abundance of fresh cells and high-quality DNA
derived from bone marrow aspirate and peripheral blood mean haematological …