The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in
polyamine biosynthesis, by beta‐adrenergic agents may have in heart hypertrophy is a …

Ornithine decarboxylase (ODC), the first enzyme of polyamine metabolism, is rapidly
upregulated in response to agents that induce a pathological cardiac hypertrophy …

These studies were designed to determine the consequences of constitutive overexpression
of ornithine decarboxylase (ODC) in the heart. Induction of ODC is known to occur in …

Ornithine decarboxylase (ODC, EC 4.1. 1.7), a rate-limiting enzyme in polyamine
biosynthesis, is known to be induced by a beta-adrenoceptor agonist, isoproterenol (ISO) …

Polyamines are thought to play an essential role in cellular hypertrophy and proliferation.
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in …

Two lines of transgenic mice were produced with constitutive expression of antizyme-1 in the
heart, driven from the cardiac α-myosin heavy chain promoter. The use of engineered …

Objective: TGF-β stimulation of cardiac myocytes induces a hypertrophic responsiveness to
β-adrenoceptor stimulation. This study investigates whether this β-adrenoceptor mediated …

The responses of AMP-activated protein kinase (AMPK) and Ornithine decarboxylase (ODC)
to isoproterenol have been examined in H9c2 cardiomyoblasts, AMPK represents the link …

The pharmacological characteristics of the myocardial adrenoceptor of the mouse have
been examined during embryogenesis by measuring ornithine decarboxylase (ODC, EC …

Background: Polyamines and nitric oxide (NO) have been involved in the pathogenesis of
cardiac hypertrophy. NO can regulate cardiac ion channels by direct actions on G-proteins …