嵌合染色体变异(mCA) 指体细胞突变大规模发生在染色体上使体内有多种核型细胞系的现象,
被视为人类衰老表型之一. mCA 与血液系统癌症, 心脑血管疾病等多种慢性病存在关联, 但mCA …

Mosaic chromosomal alteration (mCA) is referred to as large-scale somatic mutations on
chromosomes, which results in diverse karyotypes in body. The mCA is regarded as one of …

Mosaic chromosomal alterations (mCAs) are frequently observed in cancer cells and are
regarded as one of the common features of cancers. Strikingly, accumulating studies …

Somatic mosaicism is defined as the occurrence and accumulation of somatic mutations in
humans, and mosaic chromosomal alterations (mCA) are recognized as one of the aging …

Mosaic mutations in blood are common with increasing age and are prognostic markers for
cancer, cardiovascular dysfunction and other diseases. This group of acquired mutations …

Background Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses
and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many …

Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic
single-nucleotide variants have been well characterized in the human body, the patterns …

Mosaic chromosomal alterations (mCAs) are the clonal expansion of large somatically
acquired structural chromosomal changes present on the autosomes and sex …

Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers
for a host of human diseases. Here, to gain a better understanding of mCA rates in …

Mosaic chromosomal alterations (mCAs) are structural alterations associated with aging,
cancer, cardiovascular disease, infectious diseases, and mortality. The distribution of mCAs …