[HTML][HTML] The contribution of homocysteine metabolism disruption to endothelial dysfunction: state-of-the-art

R Esse, M Barroso, I Tavares de Almeida… - International journal of …, 2019 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the
metabolism of the essential amino acid methionine. Hcy is considered a risk factor for …

Endothelial dysfunction: the link between homocysteine and hydrogen sulfide

S Pushpakumar, S Kundu, U Sen - Current medicinal chemistry, 2014 - ingentaconnect.com
High level of homocysteine (hyperhomocysteinemia, HHcy) is associated with increased risk
for vascular disease. Evidence for this emerges from epidemiological studies which show …

Mechanisms of homocysteine-induced damage to the endothelial, medial and adventitial layers of the arterial wall

B Balint, VK Jepchumba, JL Guéant… - Biochimie, 2020 - Elsevier
Homocysteine (Hcy) is a non-protein forming amino acid which is the direct metabolic
precursor of methionine. Increased concentration of serum Hcy is considered a risk factor for …

Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets

Y Fu, X Wang, W Kong - British journal of pharmacology, 2018 - Wiley Online Library
Homocysteine is a sulphur‐containing non‐proteinogenic amino acid.
Hyperhomocysteinaemia (HHcy), the pathogenic elevation of plasma homocysteine as a …

[HTML][HTML] Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis

D Yuan, J Chu, H Lin, G Zhu, J Qian, Y Yu… - Frontiers in …, 2023 - frontiersin.org
Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from
methionine to cysteine. When the fasting plasma Hcy level is higher than 15 μmol/L, it is …

Homocysteine, intracellular signaling and thrombotic disorders

N Dionisio, I Jardín, GM Salido… - Current Medicinal …, 2010 - ingentaconnect.com
Homocysteine, a sulphur-containing amino acid derived from methionine, has been
presented as an independent risk factor for cardiovascular disorders, including …

Mechanisms of homocysteine toxicity in humans

J Perła-Kaján, T Twardowski, H Jakubowski - Amino acids, 2007 - Springer
Homocysteine, a non-protein amino acid, is an important risk factor for ischemic heart
disease and stroke in humans. This review provides an overview of homocysteine influence …

Imbalance of Homocysteine and H2S: Significance, Mechanisms, and Therapeutic Promise in Vascular Injury

Q Yang, GW He - Oxidative Medicine and Cellular Longevity, 2019 - Wiley Online Library
While the role of hyperhomocysteinemia in cardiovascular pathogenesis continuously draws
attention, deficiency of hydrogen sulfide (H2S) has been growingly implicated in …

Vascular oxidant stress and inflammation in hyperhomocysteinemia

L Papatheodorou, N Weiss - Antioxidants & redox signaling, 2007 - liebertpub.com
Elevated plasma levels of homocysteine are a metabolic risk factor for atherosclerotic
vascular disease, as shown in numerous clinical studies that linked elevated homocysteine …

Influence of hyperhomocysteinemia on the cellular redox state–impact on homocysteine-induced endothelial dysfunction

N Weiss, SJ Heydrick, O Postea, C Keller, JF Keaney Jr… - 2003 - degruyter.com
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis.
An increasing body of evidence has implicated oxidative stress as being contributory to …