Clonal hematopoiesis (CH), characterized by blood cells predominantly originating from a
single mutated hematopoietic stem cell, is linked to diverse aging-related diseases …

Abstract Purpose of Review Clonal hematopoiesis (CH) is a prevalent condition that results
from the acquisition of somatic mutations in hematopoietic stem cells. When these mutations …

Unlike other forms of somatic mosaicism such as cancer, CH is a premalignant state that
becomes a nearubiquitous phenomenon with advanced age. Because this condition is not …

Increasing evidence shows that conventional cardiovascular risk factors are incompletely
predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there …

Age is the dominant risk factor for most chronic human diseases; yet the mechanisms by
which aging confers this risk are largely unknown. Recently, the age-related acquisition of …

Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of
mutant hematopoietic stem cells, confers risk for multiple diseases of aging including …

The development of clonal haematopoiesis (CH), the age-related expansion of mutated
haematopoietic stem cell (HSC) clones, is influenced by genetic and non-genetic factors. To …

Clonal hematopoiesis (CH) represents the clonal expansion of hematopoietic stem cells and
their progeny driven by somatic mutations. Accurate risk assessment of CH is critical for …

Background Clonal hematopoiesis of indeterminate potential (CHIP), the age-related
expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging …

With age, acquired mutations can cause clonal expansion of hematopoietic stem cells
(HSC). This clonal hematopoiesis of indeterminate potential (CHIP) leads to an increased …