Repositioning Cannabinoids and Terpenes as Novel EGFR-TKIs Candidates for Targeted Therapy Against Cancer: A virtual screening model using CADD and …
This study examines the potential of Cannabis sativa L. plants to be repurposed as
therapeutic agents for cancer treatment through designing of hybrid Epidermal growth factor …
therapeutic agents for cancer treatment through designing of hybrid Epidermal growth factor …
Identification of potent EGFR-TKD inhibitors from NPACT database through combined computational approaches
SA Mir, A Muhammad, A Padhiary… - Journal of …, 2023 - Taylor & Francis
Cancer is the world's second leading cause of death, and there are no approved herbal
therapies. The epidermal growth factor receptor tyrosine kinase (EGFR-TK) receptor is a …
therapies. The epidermal growth factor receptor tyrosine kinase (EGFR-TK) receptor is a …
In silico investigation of cannabinoids from Cannabis sativa leaves as a potential anticancer drug to inhibit MAPK-ERK signaling pathway and EMT induction
S Iqbal, M Matsabisa - In Silico Pharmacology, 2024 - Springer
Genes related to MAPK-ERK signaling pathways, and epithelial-mesenchymal transition
induction is evolutionarily conserved and has crucial roles in the regulation of important …
induction is evolutionarily conserved and has crucial roles in the regulation of important …
Exploring EGFR inhibitors with the aid of virtual screening, docking, and dynamics simulation studies
Abstract In humans, Epidermal Growth Factor Receptor (EGFR) is linked to small-cell lung
cancer, breast cancer, and glioblastoma. Receptor kinase inhibitors against EGFR have …
cancer, breast cancer, and glioblastoma. Receptor kinase inhibitors against EGFR have …
Identification of EGFR inhibitors as potential agents for cancer therapy: pharmacophore-based modeling, molecular docking, and molecular dynamics investigations
MA Ashiru, SO Ogunyemi, OR Temionu… - Journal of Molecular …, 2023 - Springer
Context As a member of a large family of proteins that together regulate various aspects of
cell growth and development, the epidermal growth factor receptor (EGFR) is a validated …
cell growth and development, the epidermal growth factor receptor (EGFR) is a validated …
QSAR modeling, pharmacophore-based virtual screening, and ensemble docking insights into predicting potential epigallocatechin gallate (EGCG) analogs against …
UD Bommu, KK Konidala, N Pabbaraju… - Journal of Receptors …, 2019 - Taylor & Francis
Epigallocatechin gallate (EGCG) is a major polyphenols of green tea may have the
possibility to inhibit epidermal growth factor receptor (EGFR) activity and lead to reduce non …
possibility to inhibit epidermal growth factor receptor (EGFR) activity and lead to reduce non …
Molecular Modeling Targeting the ACE2 Receptor with Cannabis sativa's Active Ingredients for Antiviral Drug Discovery against SARS-CoV-2 Infections
The emergence of a novel coronavirus that later on rendered a global pandemic, caused
desperation within the communities and drove increased interest in exploring medicinal …
desperation within the communities and drove increased interest in exploring medicinal …
Structure guided design and binding analysis of EGFR inhibiting analogues of erlotinib and AEE788 using ensemble docking, molecular dynamics and MM-GBSA
VK Sharma, PP Nandekar, A Sangamwar… - RSC …, 2016 - pubs.rsc.org
Epidermal growth factor receptor (EGFR) is an important validated drug target for cancer
therapy. Some therapeutic agents targeting EGFR have been developed, however these are …
therapy. Some therapeutic agents targeting EGFR have been developed, however these are …
Computational biology and in vitro studies for anticipating cancer-related molecular targets of sweet wormwood (Artemisia annua)
Background Cancer is one of the leading causes of death worldwide. Recently, it was shown
that many natural extracts have positive effects against cancer, compared with …
that many natural extracts have positive effects against cancer, compared with …
In silico identification of potent small molecule inhibitors targeting epidermal growth factor receptor 1
Z Shi, J Chen, X Guo, L Cheng, X Guo… - Journal of Cancer …, 2018 - journals.lww.com
Background: The receptor tyrosine kinase of the epidermal growth factor receptor (EGFR,
ErbB) family played an important role in multisignaling pathways, which controlled …
ErbB) family played an important role in multisignaling pathways, which controlled …
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