Introduction: Advances in molecular biology and in the basic understanding of the
mechanisms associated with sensorineural hearing loss and other diseases of the inner ear …

Introduction: Diseases of the inner ear include those of the auditory and vestibular systems,
and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding …

There is a growing prevalence of hearing loss across the globe, with over 360 million
patients worldwide suffering from this condition. Factors such an increasingly aging …

The inner ear represents one of the most technologically challenging targets for local drug
delivery, but its clinical significance is rapidly increasing. The prevalence of sensorineural …

Optimal methods of inner ear drug delivery will depend on toxicity, therapeutic dose range,
and characteristics of the agent to be delivered. Advanced therapy development will likely …

Background: Direct delivery of drugs and other agents into the inner ear will be important for
many emerging therapies, including the treatment of degenerative disorders and guiding …

Inner ear drug delivery methods include systemic, intratympanic, and intracochlear
administration. Therapeutic technologies aim to overcome delivery barriers and to improve …

Inner ear diseases are not adequately treated by systemic drug administration mainly
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …

Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-
cochlear barrier exists, similar physiologically to the blood-brain barrier, which limits the …

One of the major challenges in treatment of auditory disorders is that many therapeutic
compounds are toxic when delivered systemically. Local intracochlear delivery methods are …