Advanced therapy-refractory solid tumors bear a dismal prognosis and constitute a major
challenge in offering effective treatment strategies. In this real-world retrospective analysis of …

Objective The objective of this multi-centre, real-world study was to examine the potential
influence of comprehensive molecular profiling on the development of treatment decisions …

Purpose Dramatic advances in our understanding of the molecular pathophysiology of
cancer, along with a rapidly expanding portfolio of molecular targeted drugs, have led to a …

Purpose Tumor genomic profiling for personalized oncology therapy is being widely applied
in clinical practice even as it is being evaluated more formally in clinical trials. Given the …

While several resources exist that interpret therapeutic significance of genomic alterations in
cancer, many regional real-world issues limit access to drugs. There is a need for a …

Introduction Molecular-matched therapies have revolutionized cancer treatment. We
evaluated the improvement in clinical outcomes of applying an in-house customized Next …

The world of molecular profiling has undergone revolutionary changes over the last few
years as knowledge, technology, and even standard clinical practice have evolved. Broad …

Patients with heavily pretreated advanced cancer or with rare tumors are difficult to treat.
Molecular profiling (MP) of tumors to identify biomarkers that predict potential outcomes with …

Treatment of rare/ultra-rare tumors is an unmet need due to a lack of standardized therapies
and clinical trials. We developed the Molecular Tumor Board (MTB), a multidisciplinary team …

Background High-throughput genomic profiling of tumour specimens facilitates the
identification of individual actionable mutations which could be used for individualised …