The need for additional genetic markers for myelodysplastic syndrome stratification: what does the future hold for prognostication?

ZK Otrock, RV Tiu, JP Maciejewski… - Expert review of …, 2013 - Taylor & Francis
Myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal
hematopoietic disorders. Metaphase cytogenetics has been the gold standard for genetic …

Molecular pathology of myelodysplastic syndromes: new developments and implications for diagnosis and treatment

X Zhang, JE Lancet, L Zhang - Leukemia & Lymphoma, 2015 - Taylor & Francis
The diagnosis of myelodysplastic syndromes (MDS) has been based on clinical
presentations, laboratory and morphological findings, and molecular and cytogenetic …

Implications of molecular genetic diversity in myelodysplastic syndromes

R Bejar - Current opinion in hematology, 2017 - journals.lww.com
Implications of molecular genetic diversity in myelodysplast... : Current Opinion in
Hematology Implications of molecular genetic diversity in myelodysplastic syndromes …

[HTML][HTML] Genetic and molecular characterization of myelodysplastic syndromes and related myeloid neoplasms

B Patel, C Hirsch, M Clemente, M Sekeres… - International journal of …, 2015 - Springer
Whole exome next generation sequencing systematically applied as a discovery tool in
myelodysplastic syndromes (MDS) has led to the identification of a large number of novel …

Molecular testing in myelodysplastic syndromes for the practicing oncologist: will the progress fulfill the promise?

A Nazha, MA Sekeres, SD Gore, AM Zeidan - The Oncologist, 2015 - academic.oup.com
Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic neoplasms that are
driven by somatically acquired genetic mutations and epigenetic alterations. Accurate risk …

[HTML][HTML] Clinical and genetic predictors of prognosis in myelodysplastic syndromes

R Bejar - Haematologica, 2014 - ncbi.nlm.nih.gov
Myelodysplastic syndromes are a collection of clonal hematopoietic disorders with a wide
range of clinical manifestations and eventual outcomes. Accurate prediction of a patient's …

Mutations and prognosis in myelodysplastic syndromes: karyotype‐adjusted analysis of targeted sequencing in 300 consecutive cases and development of a genetic …

N Gangat, M Mudireddy, TL Lasho… - American journal of …, 2018 - Wiley Online Library
To develop a genetic risk model for primary myelodysplastic syndromes (MDS), we queried
the prognostic significance of next‐generation sequencing (NGS)‐derived mutations, in the …

The evolving role of genomic testing in assessing prognosis of patients with myelodysplastic syndromes

DP Steensma - Best practice & research Clinical haematology, 2017 - Elsevier
The introduction into routine hematology-oncology clinical practice of molecular genetic
testing assays based on next-generation sequencing platforms is prompting reassessment …

Myelodysplastic syndromes

PL Nguyen, RP Hasserjian - Hematopathology, 2018 - Elsevier
The myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic
stem cell disorders characterized by ineffective hematopoiesis. Clinically, patients present …

Current state of prognostication and risk stratification in myelodysplastic syndromes

AM Zeidan, SD Gore, E Padron… - Current opinion in …, 2015 - journals.lww.com
How to best use the results of molecular mutation testing to inform clinical decision making
in MDS is still a work in progress. Important steps in this direction include standardization in …