Improving oral absorption via drug-loaded nanocarriers: absorption mechanisms, intestinal models and rational fabrication

MA Shahbazi, HA Santos - Current drug metabolism, 2013 - ingentaconnect.com
Although it is acknowledged that the main impediment of orally administered therapeutic
agents is their extensive and changeable pre-systemic metabolism, low absorption and …

Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery

E Roger, F Lagarce, E Garcion, JP Benoit - Nanomedicine, 2010 - Future Medicine
Oral route is the most common route for the delivery of drugs because it is simple to
implement and improves patient compliance and quality of life. However, oral absorption is …

[HTML][HTML] Intestinal absorption study: Challenges and absorption enhancement strategies in improving oral drug delivery

M Azman, AH Sabri, QK Anjani, MF Mustaffa… - Pharmaceuticals, 2022 - mdpi.com
The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

Reprint of: Nanocarrier systems for oral drug delivery: Do we really need them?

A Bernkop-Schnürch - European Journal of Pharmaceutical Sciences, 2013 - Elsevier
In particular since the last two decades there is constantly increasing interest in nanocarrier
systems. They are utilized in order to overcome the major challenges being associated with …

Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at permeability assessment methods and pharmacokinetic properties …

D Babadi, S Dadashzadeh, M Osouli… - Journal of controlled …, 2020 - Elsevier
The therapeutic efficacy of orally administered drugs is often restricted by their inherent
limited oral bioavailability. Low water solubility, limited permeability through the intestinal …

The performance of nanocarriers for transmucosal drug delivery

N Csaba, M Garcia-Fuentes… - Expert opinion on drug …, 2006 - Taylor & Francis
Most of the newly designed drug molecules are characterised by low solubility in aqueous
medium, low permeability through biological membranes and/or an insufficient stability in …

The challenges of oral drug delivery via nanocarriers

J Reinholz, K Landfester, V Mailänder - Drug delivery, 2018 - Taylor & Francis
The oral application of pharmaceuticals is unarguably the most convenient method of
application. Especially for protein-or peptide-based drugs, however, the effectiveness is …

Oral drug delivery platforms for biomedical applications

J Ouyang, Z Zhang, B Deng, J Liu, L Wang, H Liu… - Materials Today, 2023 - Elsevier
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …

Challenges in oral drug delivery: a nano-based strategy to overcome

P Viswanathan, Y Muralidaran, G Ragavan - Nanostructures for oral …, 2017 - Elsevier
Oral drug delivery (ODD) is the most preferred and convenient route of drug administration
due to high patient compliance, cost-effectiveness, least sterility constraints, flexibility in the …

[HTML][HTML] Research on the fate of polymeric nanoparticles in the process of the intestinal absorption based on model nanoparticles with various characteristics: size …

S Guo, Y Liang, L Liu, M Yin, A Wang, K Sun… - Journal of …, 2021 - Springer
Background The use of drug nanocarriers to encapsulate drugs for oral administration may
become an important strategy in addressing the challenging oral absorption of some drugs …