Background A subset of patients with chronic rhinosinusitis (CRS) has refractory disease.
The risk factors for refractory CRS include atopy, a disrupted mucociliary transport system …

Background Several studies have shown a high prevalence of immunoglobulin deficiencies
in patients with chronic rhinosinusitis (CRS). Objective We sought to perform a systematic …

Chronic rhinosinusitis (CRS) is estimated to affect over 35 million people. However, not all
patients with the diagnosis respond to standard medical and surgical treatments. Although …

Background Specific antibody deficiency (SAD) involves a deficient response to a
polysaccharide vaccine in the setting of normal immunoglobulin G (IgG) levels and chronic …

Background Specific antibody deficiency may predispose patients to recurrent respiratory
tract infections. There is limited literature assessing specific antibody deficiency in chronic …

Background Despite the increased identification of specific antibody deficiency (SAD) in
chronic rhinosinusitis (CRS), little is known about the relationship between SAD severity and …

Conclusion: Humoral immunodeficiency is present in a significant proportion of patients with
refractory rhinosinusitis. The majority of these deficiencies are subtle IgG subclass deficits …

Introduction: Chronic rhinosinusitis (CRS) is a prevalent disease with a high annual cost of
treatment. Immune deficiencies are more common in individuals with CRS and should be …

Chronic rhinosinusitis (CRS) is a persistent inflammatory disease that affects a multitude of
people worldwide. The pathogenesis of CRS involves many factors including genetics …

The purpose of this study is to readdress the issue of primary humoral immunodeficiency
frequency and pattern in medically resistant chronic rhinosinusitis (CRS) based on the new …