Pentafuhalol-B, a Phlorotannin from Brown Algae, Strongly Inhibits the PLK-1 Overexpression in Cancer Cells as Revealed by Computational Analysis
WA Ansari, SO Rab, M Saquib, A Sarfraz, MK Hussain… - Molecules, 2023 - mdpi.com
Polo-like kinase-1 (PLK-1) is an essential mitotic serine/threonine (Ser/Thr) kinase that
belongs to the Polo-like kinase (PLK) family and is overexpressed in non-small cell lung …
belongs to the Polo-like kinase (PLK) family and is overexpressed in non-small cell lung …
Pharmacoinformatics approach for the identification of Polo-like kinase-1 inhibitors from natural sources as anti-cancer agents
Abstract Polo-like kinase-1 (PLK-1) plays a key role in cell cycle progression during mitosis.
Overexpression/dysfunction of PLK-1 is directly associated with cancerous transformation …
Overexpression/dysfunction of PLK-1 is directly associated with cancerous transformation …
Identification of a high affinity selective inhibitor of Polo-like kinase 1 for cancer chemotherapy by computational approach
Abstract Polo-like kinase (Plk) 1 is a key regulator of the cell cycle during mitotic phase and
is an attractive anti-mitotic drug target for cancer. Plk1 is a member of Ser/Thr kinase family …
is an attractive anti-mitotic drug target for cancer. Plk1 is a member of Ser/Thr kinase family …
The molecular docking of 1, 4-naphthoquinone derivatives as inhibitors of Polo-like kinase 1 using Molegro Virtual Docker
Abstract Polo-like kinase 1 (Plk1) is over expressed in many types of human cancers, and
has been implicated as an adverse prognostic marker for cancer patients. Plk1 is localized …
has been implicated as an adverse prognostic marker for cancer patients. Plk1 is localized …
In silico identification of putative bifunctional Plk1 inhibitors by integrative virtual screening and structural dynamics approach
Polo like kinase (Plk1) is a master regulator of cell cycle and considered as next generation
antimitotic target in human. As Plk1 predominantly expresses in the dividing cells with a …
antimitotic target in human. As Plk1 predominantly expresses in the dividing cells with a …
Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold
MM Zhan, Y Yang, J Luo, XX Zhang, X Xiao, S Li… - European Journal of …, 2018 - Elsevier
Abstract Polo-like kinase 2 (Plk2) is a potential target for the treatment of cancer, which
displays an important role in tumor cell proliferation and survival. In this report, according to …
displays an important role in tumor cell proliferation and survival. In this report, according to …
In-silico design and synthesis of N9-substituted β-Carbolines as PLK-1 inhibitors and their in-vitro/in-vivo tumor suppressing evaluation
GP Jeyapal, R Krishnasamy, CK Suzuki… - Bioorganic …, 2019 - Elsevier
A new series of β-Carboline/Schiff bases was designed, synthesized, characterised and
biologically evaluated as inhibitors of PLK-1. The synthesized compounds exhibited strong …
biologically evaluated as inhibitors of PLK-1. The synthesized compounds exhibited strong …
Identification of Green Tea Catechins as Potent Inhibitors of the Polo‐Box Domain of Polo‐Like kinase 1
HM Shan, Y Shi, J Quan - ChemMedChem, 2015 - Wiley Online Library
Abstract Polo‐like kinase 1 (PLK1) plays crucial functions in multiple stages of mitosis and is
considered to be a potential drug target for cancer therapy. The functions of PLK1 are …
considered to be a potential drug target for cancer therapy. The functions of PLK1 are …
[HTML][HTML] An enzoinformatics study targeting polo-like kinases-1 enzyme: Comparative assessment of anticancer potential of compounds isolated from leaves of …
Natural products from plant sources, embracing inherently ample structural diversity than
synthetic ones are the major sources of anticancer agents and will constantly play as …
synthetic ones are the major sources of anticancer agents and will constantly play as …
Virtual screening of natural compounds as selective inhibitors of polo-like kinase-1 at C-terminal polo box and N-terminal catalytic domain
The over-expression of Polo-like kinase-1 (PLK1) is associated with cancer prognosis due to
its pivotal role in cell proliferation. The N-terminal catalytic domain (NCD) and C-terminal …
its pivotal role in cell proliferation. The N-terminal catalytic domain (NCD) and C-terminal …