Pathogenesis of depression in Alzheimer's disease

Q Zhan, F Kong, S Shao, B Zhang, S Huang - Neurochemical Research, 2024 - Springer
Depression is a prevalent occurrence among Alzheimer's disease (AD) patients, yet its
underlying mechanism remains unclear. Recent investigations have revealed that several …

The putative neurodegenerative links between depression and Alzheimer's disease

S Wuwongse, RCC Chang, ACK Law - Progress in Neurobiology, 2010 - Elsevier
Alzheimer's disease (AD) is the leading neurodegenerative cause of dementia in the elderly.
Thus far, there is no curative treatment for this devastating condition, thereby creating …

Depression and Alzheimer's disease: neurobiological links and common pharmacological targets

F Caraci, A Copani, F Nicoletti, F Drago - European journal of …, 2010 - Elsevier
Depression is one of the most prevalent and life-threatening forms of mental illnesses,
whereas Alzheimer's disease is a neurodegenerative disorder that affects more than 37 …

Neuropathological relationship between major depression and dementia: a hypothetical model and review

HK Kim, PV Nunes, KC Oliveira, LT Young… - Progress in Neuro …, 2016 - Elsevier
Major depression (MDD) is a chronic psychiatric condition in which patients often show
increasing cognitive impairment with recurring episodes. Neurodegeneration may play an …

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Depression in Alzheimer's disease: epidemiology, mechanisms, and management

S Chi, JT Yu, MS Tan, L Tan - Journal of Alzheimer's disease, 2014 - content.iospress.com
Depression occurs with a high prevalence of up to 50% in patients with Alzheimer's disease
(AD) and increases the caregivers' burden. Depression symptoms can precede clinical …

Major depression, cognitive dysfunction and Alzheimer's disease: is there a link?

ASR Sierksma, DLA van den Hove… - European journal of …, 2010 - Elsevier
Major depression (MD) is a severe mental disorder characterized by alterations in mood and
cognition, with disease severity correlating inversely with cognition scores. Neuropathology …

Converged avenues: depression and Alzheimer's disease–shared pathophysiology and novel therapeutics

S Bajaj, R Mahesh - Molecular Biology Reports, 2024 - Springer
Depression, a highly prevalent disorder affecting over 280 million people worldwide, is
comorbid with many neurological disorders, particularly Alzheimer's disease (AD) …

What is the association between depression and Alzheimer's disease?

N Tsuno, A Homma - Expert review of neurotherapeutics, 2009 - Taylor & Francis
Depression and dementia, in particular Alzheimer's disease (AD), are critically important
issues in the mental health of old age. Both conditions apparently reduce quality of life and …

Alzheimer Disease—Link With Major Depressive Disorder and Efficacy of Antidepressants in Modifying its Trajectory

N Fakih, M Fakhoury - Journal of Psychiatric Practice®, 2024 - journals.lww.com
Alzheimer disease (AD) is a devastating neurodegenerative disorder that affects millions of
individuals worldwide, with no effective cure. The main symptoms include learning and …