To produce the health-associated metabolite propionate, gut microbes require vitamin B12
as a cofactor to convert succinate to propionate. B12 is sourced in the human gut from the …

Many commensal gut microbes are recognized for their potential to synthesize vitamin B12,
offering a promising avenue to address deficiencies through probiotic supplementation …

Vitamin B12 (cobalamin) is present in the human lower gastrointestinal tract either coming
from the unabsorbed dietary fraction or from in situ production of the gut microbiota …

Currently, obesity is a critical global public health burden. Numerous studies have
demonstrated the regulation of the pathogenesis of obesity and metabolic abnormalities by …

The dense microbial ecosystem within the gut is connected through a complex web of
metabolic interactions. In this issue of Cell Host & Microbe, Degnan et al.(2014) establish the …

Since propionate exerts several physiological effects, maintenance of its normal colonic
fermentation is essential. To investigate whether vitamin B12 (VB12) is essential for normal …

The gut microbiota is closely related to good health; thus, there have been extensive efforts
dedicated to improving health by controlling the gut microbial environment. Probiotics and …

Nutrition-gut cross-talk holds a vital position in sustaining intestinal function, and
micronutrient metabolism has emerged as the foremost metabolic pathway to preserve gut …

2-hydroxybutyric acid (2HB) serves as an important regulatory factor in a variety of diseases.
The circulating level of 2HB in serum is significantly higher in multiple diseases, such as …

The microbial mechanisms and key metabolites that shape the composition of the human
gut microbiota are largely unknown, impeding efforts to manipulate dysbiotic microbial …