The role of iron metabolism, lipid metabolism, and redox homeostasis in Alzheimer's disease: from the perspective of ferroptosis

L Wu, X Xian, Z Tan, F Dong, G Xu, M Zhang… - Molecular …, 2023 - Springer
In the development of Alzheimer's disease (AD), cell death is common. Novel cell death form—
ferroptosis is discovered in recent years. Ferroptosis is an iron-regulated programmed cell …

The potential role of ferroptosis in Alzheimer's disease

G Zhang, Y Zhang, Y Shen, Y Wang… - Journal of …, 2021 - content.iospress.com
Alzheimer's disease (AD) is the most prevalent cause of dementia, accounting for
approximately 60%–80% of all cases. Although much effort has been made over the years …

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

M Jakaria, AA Belaidi, AI Bush… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

The key roles of organelles and ferroptosis in Alzheimerʼs disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Journal of …, 2022 - Wiley Online Library
Alzheimerʼs disease (AD), an age‐related neurodegenerative disease, is a striking global
health problem. Ferroptosis is a newly discovered form of cell death characterized by iron …

Spotlight on ferroptosis: iron-dependent cell death in Alzheimer's disease

A Ashraf, PW So - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease is an emerging global epidemic that is becoming increasingly
unsustainable. Most of the clinical trials have been centered around targeting β-amyloid and …

Iron dyshomeostasis and ferroptosis in Alzheimer's disease: Molecular mechanisms of cell death and novel therapeutic drugs and targets for AD

Y Zhang, M Wang, W Chang - Frontiers in Pharmacology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a degenerative disease of the central nervous system that is the
most common type of senile dementia. Ferroptosis is a new type of iron-dependent …

Ferroptosis: A potential therapeutic target for Alzheimer's disease

L Yang, J Nao - Reviews in the Neurosciences, 2023 - degruyter.com
The most prevalent dementia-causing neurodegenerative condition is Alzheimer's disease
(AD). The aberrant buildup of amyloid β and tau hyperphosphorylation are the two most well …

Ferroptosis, a potential therapeutic target in Alzheimer's disease

K Chen, X Jiang, M Wu, X Cao, W Bao… - Frontiers in Cell and …, 2021 - frontiersin.org
Cell death is a common phenomenon in the progression of Alzheimer's disease (AD).
However, the mechanism of triggering the death of neuronal cells remains unclear …

Ferroptosis, a recent defined form of critical cell death in neurological disorders

J Wu, Q Tuo, P Lei - Journal of Molecular Neuroscience, 2018 - Springer
Ferroptosis is a recently defined form of cell death with the involvement of iron and reactive
oxygen species (ROS), which is distinct from apoptosis, autophagy and other forms of cell …

The mechanisms of ferroptosis and its role in alzheimer's disease

H Ma, Y Dong, Y Chu, Y Guo, L Li - Frontiers in Molecular …, 2022 - frontiersin.org
Alzheimer's disease (AD) accounts for two-thirds of all dementia cases, affecting 50 million
people worldwide. Only four of the more than 100 AD drugs developed thus far have …