Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
Tipping the metabolic scales towards increased longevity in mammals
A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose
homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing …
homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing …
[HTML][HTML] Mitochondria in the signaling pathways that control longevity and health span
M Akbari, TBL Kirkwood, VA Bohr - Ageing research reviews, 2019 - Elsevier
Genetic and pharmacological intervention studies have identified evolutionarily conserved
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …
and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing …
Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?
G López-Lluch, JD Hernández-Camacho… - Biogerontology, 2018 - Springer
Mitochondria are key in the metabolism of aerobic organisms and in ageing progression and
age-related diseases. Mitochondria are essential for obtaining ATP from glucose and fatty …
age-related diseases. Mitochondria are essential for obtaining ATP from glucose and fatty …
[HTML][HTML] The mitochondrial basis of aging and age-related disorders
S Srivastava - Genes, 2017 - mdpi.com
Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …
function leading to increased risk of disease and mortality. Among diverse factors that …
Mitochondrial dysfunction in age‐related metabolic disorders
V Natarajan, R Chawla, T Mah, R Vivekanandan… - …, 2020 - Wiley Online Library
Aging is a natural biological process in living organisms characterized by receding
bioenergetics. Mitochondria are crucial for cellular bioenergetics and thus an important …
bioenergetics. Mitochondria are crucial for cellular bioenergetics and thus an important …
Mitochondrial function in ageing: coordination with signalling and transcriptional pathways
Mitochondrial dysfunction entailing decreased energy‐transducing capacity and perturbed
redox homeostasis is an early and sometimes initiating event in ageing and age‐related …
redox homeostasis is an early and sometimes initiating event in ageing and age‐related …
[HTML][HTML] Mitochondria: multifaceted regulators of aging
Aging is accompanied by a time-dependent progressive deterioration of multiple factors of
the cellular system. The past several decades have witnessed major leaps in our …
the cellular system. The past several decades have witnessed major leaps in our …
Aging: All roads lead to mitochondria
Mitochondria were described as early as 1890 as ubiquitous intracellular structures by
Ernster and Schatz (1981)[1]. Since then, the accretion of knowledge in the past century has …
Ernster and Schatz (1981)[1]. Since then, the accretion of knowledge in the past century has …
Mitochondrial pathways in human health and aging
R Bornstein, B Gonzalez, SC Johnson - Mitochondrion, 2020 - Elsevier
Mitochondria are eukaryotic organelles known best for their roles in energy production and
metabolism. While often thought of as simply the 'powerhouse of the cell,'these organelles …
metabolism. While often thought of as simply the 'powerhouse of the cell,'these organelles …