Nanotechnology-inspired extracellular vesicles theranostics for diagnosis and therapy of central nervous system diseases

T Tian, S Qiao, BA Tannous - ACS Applied Materials & Interfaces, 2022 - ACS Publications
Shuttling various bioactive substances across the blood–brain barrier (BBB) bidirectionally,
extracellular vesicles (EVs) have been opening new frontiers for the diagnosis and therapy …

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

HK Choi, M Chen, LL Goldston, KB Lee - Nano Convergence, 2024 - Springer
Abstract Central Nervous System (CNS) disorders represent a profound public health
challenge that affects millions of people around the world. Diseases such as Alzheimer's …

Improving isolation of extracellular vesicles by utilizing nanomaterials

H Zhang, Q Zhang, Y Deng, M Chen, C Yang - Membranes, 2021 - mdpi.com
Extracellular vesicles (EVs) as the new form of cellular communication have been
demonstrated their potential use for disease diagnosis, prognosis and treatment. EVs are …

Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications

A Onkar, F Khan, A Goenka… - … Applied Materials & …, 2024 - ACS Publications
Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …

Bioengineering extracellular vesicles as novel nanocarriers towards brain disorders

J Wu, L Ma, D Sun, X Zhang, J Cui, Y Du, Y Guo… - Nano Research, 2023 - Springer
Despite noteworthy technological progress and promising preclinical trials, brain disorders
are still the leading causes of death globally. Extracellular vesicles (EVs), nano-/micro-sized …

Emerging prospects of extracellular vesicles for brain disease theranostics

R Wang, X Wang, Y Zhang, H Zhao, J Cui, J Li… - Journal of Controlled …, 2022 - Elsevier
In the past decade, bio-nanoparticles inspired by nature with advantageous properties have
attracted extensive interest for accurate diagnosis and effective treatment. Extracellular …

Advances in extracellular vesicle nanotechnology for precision theranostics

Q Wu, S Fu, H Xiao, J Du, F Cheng, S Wan… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) have increasingly been recognized as important cell surrogates
influencing many pathophysiological processes, including cellular homeostasis, cancer …

Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine

Z Fan, C Jiang, Y Wang, K Wang, J Marsh… - Nanoscale …, 2022 - pubs.rsc.org
Extracellular vesicles (EVs), as natural carriers of bioactive cargo, have a unique
micro/nanostructure, bioactive composition, and characteristic morphology, as well as …

Extracellular vesicles: A bright star of nanomedicine

P Wu, B Zhang, DKW Ocansey, W Xu, H Qian - Biomaterials, 2021 - Elsevier
Extracellular vesicles (EVs) have unique structural, compositional, and morphological
characteristics as well as predominant physiochemical stability and biocompatibility …

Most recent advances and applications of extracellular vesicles in tackling neurological challenges

M Kaur, S Fusco, B Van den Broek… - Medicinal Research …, 2024 - Wiley Online Library
Over the past few decades, there has been a notable increase in the global burden of
central nervous system (CNS) diseases. Despite advances in technology and therapeutic …