Vitamin B12 (Cbl) is needed for just two metabolic reactions in man, the methylation of
homocysteine to methionine (cofactor methyl-Cbl) and the conversion of methylmalonyl-CoA …

Vitamin B 12 (Cbl) is needed for just two metabolic reactions in man, the methylation of
homocysteine to methionine (cofactor methyl-Cbl) and the conversion of methylmalonyl-CoA …

The absorption and intracellular utilisation of dietary cobalamin (Cbl) is complex. Inherited
disorders can occur at each step. Those affecting absorption and transport of Cbl are …

Abstract Cobalamin (Cbl, vitamin B 12) is a widely distributed, cobalt-containing, water-
soluble vitamin that is not found in higher plants. Cb1 is needed for only two reactions in …

Patients with disorders of intracellular Cbl metabolism typically have serum Cbl levels within
the reference range, although levels may be reduced in the cblF and cblJ disorders …

This review gives an overview of clinical characteristics, treatment and outcome of nutritional
and acquired cobalamin (Cbl; synonym: vitamin B12) deficiencies, inborn errors of Cbl …

Cobalamin (vitamin B 12) is required for activity of the enzymes methylmalonyl-CoA mutase
and methionine synthase in human cells. Inborn errors affecting cobalamin uptake or …

AN increasing variety of hereditary disorders of intracellular cobalamin metabolism, usually
first detected because of the presence of methylmalonic aciduria (cblA, cblB, and cblF …

Patients with inherited disorders affecting cobalamin (Cbl) absorption or metabolism show
elevations of homocysteine or methylmalonic acid, either alone or in combination. For those …

Abstract Cobalamin C (Cbl-C) defect is the most common inborn cobalamin metabolism
error; it causes impaired conversion of dietary vitamin B12 into its two metabolically active …