Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

The metabolic demands of the brain are met by oxygen and glucose, supplied by a complex
hierarchical network of microvessels (arterioles, capillaries, and venules). Transient …

Molecular cross talk between the nervous and vascular systems is necessary to maintain the
correct coupling of organ structure and function. Molecular pathways shared by both …

Vertebrates have acquired complex high-order functions facilitated by the dispersion of
vascular and neural networks to every corner of the body. Blood vessels deliver oxygen and …

Adequate supply of blood and structural and functional integrity of blood vessels are key to
normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain …

Proper functioning of the brain is dependent on integrity of the cerebral vasculature. During
ageing, a number of factors including aortic or arterial stiffness, autonomic dysregulation …

The neurovascular system (NVS), which consisted of neurons, glia, and vascular cells, is a
functional and structural unit of the brain. The NVS regulates blood-brain barrier (BBB) …

Understanding the bases of aging-related cognitive decline remains a central challenge in
neurobiology. Quantitative studies reveal little change in the number of neurons or synapses …

Efficient blood supply to the brain is of paramount importance to its normal functioning and
improper blood flow can result in potentially devastating neurological consequences …

The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells
through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular …