[HTML][HTML] Ginsenoside Rg1 reduces β‑amyloid levels by inhibiting CDΚ5‑induced PPARγ phosphorylation in a neuron model of Alzheimer's disease

Q Quan, X Li, J Feng, J Hou… - Molecular Medicine …, 2020 - spandidos-publications.com
The accumulation of β‑amyloid peptides (Aβ) in the brain is a hallmark of Alzheimer's
disease (AD). Studies have indicated that ginsenoside Rg1, a primary component of …

Ginsenoside Rh1 exerts neuroprotective effects by activating the PI3K/Akt pathway in amyloid-β induced SH-SY5Y cells

M Park, SH Kim, HJ Lee - Applied Sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of β-amyloid plaques and hyperphosphorylated tau proteins in the brain. Cell …

Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells

L Chen, Z Lin, Y Zhu, N Lin, J Zhang, X Pan… - European journal of …, 2012 - Elsevier
The level of β-site APP-cleaving enzyme 1 (BACE1) has been documented to increase in
the brains of patients with Alzheimer's disease, which has resulted in elevation of β-amyloid …

Ginsenoside Rg1 Decreases Aβ1–42 Level by Upregulating PPARγ and IDE Expression in the Hippocampus of a Rat Model of Alzheimer's Disease

QK Quan, J Wang, X Li, Y Wang - PloS one, 2013 - journals.plos.org
Background and Purpose The present study was designed to examine the effects of
ginsenoside Rg1 on expression of peroxisome proliferator-activated receptor γ (PPARγ) and …

Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease☆

X Li, M Li, Y Li, Q Quan, J Wang - Neural Regeneration Research, 2012 - journals.lww.com
Ginsenoside Rg1 inhibits oxidation, aging and cell apoptosis, and improves cognitive
function. In this study, we pretreated rat brain tissue sections with ginsenoside Rg1, and …

Ginsenoside Rg1 attenuates amyloid-β content, regulates PKA/CREB activity, and improves cognitive performance in SAMP8 mice

YQ Shi, TW Huang, LM Chen, XD Pan… - Journal of …, 2010 - content.iospress.com
It is well established that the presence of soluble amyloid-β protein (Aβ) correlates with the
severity of dementia in Alzheimer's disease (AD). Several lines of evidence indicate that …

Pioglitazone Reduces β Amyloid Levels via Inhibition of PPARγ Phosphorylation in a Neuronal Model of Alzheimer's Disease

Q Quan, Y Qian, X Li, M Li - Frontiers in aging neuroscience, 2019 - frontiersin.org
It has been demonstrated that peroxisome proliferator-activated receptor γ (PPARγ) can
regulate the transcription of its target gene, insulin-degrading enzyme (IDE), and thus …

Ginsenoside Rg2 protects PC12 cells against β-amyloid25-35-induced apoptosis via the phosphoinositide 3-kinase/Akt pathway

J Cui, J Wang, M Zheng, D Gou, C Liu… - Chemico-biological …, 2017 - Elsevier
Alzheimer's disease (AD) is one of the most debilitating neurodegenerative diseases in an
aging population. Excessive accumulation of β-amyloid (Aβ) has been proposed as a pivotal …

[HTML][HTML] Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model

F Fang, X Chen, T Huang, LF Lue, JS Luddy… - … et Biophysica Acta (BBA …, 2012 - Elsevier
There has been no extensive characterization of the effects of Ginsenoside Rg1, a
pharmacological active component purified from the nature product ginseng, in an …

Protective effects of ginsenoside Rg2 against memory impairment and neuronal death induced by Aβ25-35 in rats

J Cui, R Shan, Y Cao, Y Zhou, C Liu, Y Fan - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Ginsenoside Rg2 is an important ingredient of
Panax ginseng which often appears in ancient prescriptions for forgetfulness. Ginsenoside …