Synthesis of a diverse set of azoles and their utilizations as an amide isostere in the design
of HIV integrase inhibitors is described. The Letter identified thiazole, oxazole, and …

This communication details both the syntheses and biological evaluation of a novel class of
HIV-1 integrase inhibitors. When the quinoline moiety is replaced with the quinoxoline …

A novel class of tri-cyclic HIV integrase inhibitors were designed based on conformational
analysis of 1, 6-naphthyridine carboxamide compound L-870810 and docking the designed …

A series of HIV-1 integrase inhibitors containing a novel metal binding motif consisting of the
8-hydroxy-1, 6-naphthyridine core and either an oxadiazole or triazole has been identified …

Existing AIDS therapies are out of reach for most HIV-infected people in developing
countries and, where available, they are limited by their toxicity and their cost. New anti-HIV …

A series of novel tricyclic inhibitors of HIV-1 integrase enzyme was prepared. The effect of
substitution at C-6 of the 9-hydroxy-6, 7-dihydropyrrolo [3, 4-g] quinolin-8-one compounds …

Based on data derived from a large number of HIV-1 integrase inhibitors, similar structural
features can be observed, which consist of two aryl units separated by a central linker. For …

Human immunodeficiency virus type-1 integrase is an essential enzyme for effective viral
replication and hence a valid target for the design of inhibitors. We report here on the design …

Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold -
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The novel HIV-1 integrase inhibitor 1, discovered in our laboratory, exhibits potent anti-HIV
activity against a diverse set of HIV-1 isolates and also against HIV-2 and SIV. In addition …