Objective The aim of this research was to perform a systematic review to identify all
randomized controlled trials (RCTs) evaluating the efficacy and safety of add‐on celecoxib …

Background Numerous studies have reported that inflammation is closely associated with
depression, and adjunctive non-steroidal anti-inflammatory drug (NSAID) treatment has …

The effects of celecoxib on a broad spectrum of mood disorders and on inflammatory
parameters have not yet been comprehensively evaluated. The aim of this study was to …

Background: The pathophysiology of depression is associated with the hyperactivity of
immune inflammatory responses. Cyclooxygenase‐2 inhibitors such as celecoxib reduce …

BACKGROUND Anti-inflammation drugs were uncovered to be a potential therapy for
depression. Celecoxib as a selective COX2 inhibitor is also one anti-inflammation drugs …

Given the role of low-grade inflammation in the pathophysiology of major depressive
disorder (MDD), anti-inflammatory strategies may improve treatment outcomes in some …

Objective To investigate whether the cox‐2 inhibitor celecoxib has antidepressant effects in
bipolar disorder (BD) patients during depressive or mixed phases. Methods We studied 28 …

Importance Several studies have reported antidepressant effects of anti-inflammatory
treatment; however, the results have been conflicting and detrimental adverse effects may …

BACKGROUND: It has been proposed that the mechanism of the antidepressant effect of
celecoxib is linked to its anti-inflammatory action and particularly its inhibitory effect on pro …

Introduction As the role of (neuro) inflammation in depression pathophysiology is emerging,
augmentation of antidepressant treatments with anti-inflammatory drugs have shown …