Traumatic brain injury (TBI) often damages axons in white matter tracts and causes corpus
callosum (CC) atrophy in chronic TBI patients. Injured axons encounter irreversible damage …

Traumatic brain injury (TBI) causes chronic symptoms and increased risk of
neurodegeneration. Axons in white matter tracts, such as the corpus callosum (CC), are …

Axonal degeneration is a critical, early event in many acute and chronic neurological
disorders. It has been consistently observed after traumatic brain injury, but whether axon …

One of the consistent pathologies associated with both clinical and experimental traumatic
brain injury is axonal injury, especially following mild traumatic brain injury (or concussive …

Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or
unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a …

Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …

Protecting the nervous system from chronic effects of physical and chemical stress is a
pressing clinical challenge. The obligate pro-degenerative protein Sarm1 is essential for …

Axonal degeneration contributes to the pathogenesis of many neurodegenerative disorders,
motivating efforts to dissect the mechanism of pathological axon loss in order to develop …

Activation of the pro-degenerative protein SARM1 after diverse physical and disease-
relevant injuries causes programmed axon degeneration. Original studies indicate that …

Since SARM1 mutations have been identified in human neurological disease, SARM1
inhibition has become an attractive therapeutic strategy to preserve axons in a variety of …