The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

The solubility enhancement process of hydrophobic drugs plays a key role in the formulation
development to achieve the bioavailability and therapeutic action of the drug at the target …

High-throughput screening (HTS) methodologies for lead identification in drug discovery
were developed in the 1980s to enable the utilization of advances in genomics and …

The oral bioavailability of BCS (biopharmaceutics classification system) class II drugs with
poor solubility and reasonable permeability is limited by the drug dissolution step from drug …

A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to
reach market due to their poor aqueous solubility. For orally administered drugs solubility is …

Most of the drugs in the developmental pipeline are emerging from the High-Throughput
Screening methodology resulting in increased molecular weights and thus consequential …

Introduction: In the past two decades, there has been a spiraling increase in the complexity
and specificity of drug–receptor targets. It is possible to design drugs for these diverse …

Solubility is not to be confused with the ability to dissolve or liquefy a substance, since this
process may occur not only because of dissolution but also because of a chemical reaction …