More than 80% of all cases of deafness are related to the death or degeneration of cochlear
hair cells and the associated spiral ganglion neurons, and a lack of regeneration of these …

Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the
auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC …

Atoh1 overexpression is essential for hair cell (HC) regeneration in the sensory epithelium of
mammalian auditory and vestibular organs. However, Atoh1 overexpression alone cannot …

Damage or loss of auditory hair cells leads to irreversible sensorineural hearing loss in
human, thus regeneration of these cells to reconstruct auditory sensory epithelium holds the …

Across species, expression of the basic helix-loop-helix transcription factor ATOH1 promotes
differentiation of cochlear supporting cells to sensory hair cells required for hearing. In …

Hearing impairment is primarily attributed to inner ear hair cell (HC) defects that
subsequently lead to spiral ganglion neuron (SGN) loss. The HC loss cannot be self …

Hearing impairment due to the loss of sensory hair cells is permanent in humans.
Considerable interest targets the hair cell differentiation factor Atoh1 as a potential tool with …

ATOH1 is a basic Helix-Loop-Helix transcription factor crucial for hair cell (HC) differentiation
in the inner ear. In order to identify ATOH1 target genes, we performed a genome-wide …

In the developing cochlea, sensory hair cell differentiation depends on the regulated
expression of the bHLH transcription factor Atoh1. In mammals, if hair cells die they do not …

Atonal homolog 1 (Atoh1) is a basic helix-loop-helix transcription factor that is essential for
inner ear hair cell differentiation. Previous studies have reported that Atoh1 gene transfer …