[HTML][HTML] Atoh1 regulation in the cochlea: more than just transcription
YF Cheng - Journal of Zhejiang University. Science. B, 2019 - ncbi.nlm.nih.gov
More than 80% of all cases of deafness are related to the death or degeneration of cochlear
hair cells and the associated spiral ganglion neurons, and a lack of regeneration of these …
hair cells and the associated spiral ganglion neurons, and a lack of regeneration of these …
[HTML][HTML] Atoh1 as a coordinator of sensory hair cell development and regeneration in the cochlea
S Lee, HS Jeong, HH Cho - Chonnam Medical Journal, 2017 - synapse.koreamed.org
Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the
auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC …
auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC …
[HTML][HTML] The proper timing of Atoh1 expression is pivotal for hair cell subtype differentiation and the establishment of inner ear function
D You, W Ni, Y Huang, Q Zhou, Y Zhang… - Cellular and Molecular …, 2023 - Springer
Atoh1 overexpression is essential for hair cell (HC) regeneration in the sensory epithelium of
mammalian auditory and vestibular organs. However, Atoh1 overexpression alone cannot …
mammalian auditory and vestibular organs. However, Atoh1 overexpression alone cannot …
[HTML][HTML] Atoh1 and other related key regulators in the development of auditory sensory epithelium in the mammalian inner ear: function and interplay
C Zhong, Y Fu, W Pan, J Yu, J Wang - Developmental biology, 2019 - Elsevier
Damage or loss of auditory hair cells leads to irreversible sensorineural hearing loss in
human, thus regeneration of these cells to reconstruct auditory sensory epithelium holds the …
human, thus regeneration of these cells to reconstruct auditory sensory epithelium holds the …
[HTML][HTML] HIC1 represses Atoh1 transcription and hair cell differentiation in the cochlea
D Abdul-Aziz, N Hathiramani, L Phung, V Sykopetrites… - Stem Cell Reports, 2021 - cell.com
Across species, expression of the basic helix-loop-helix transcription factor ATOH1 promotes
differentiation of cochlear supporting cells to sensory hair cells required for hearing. In …
differentiation of cochlear supporting cells to sensory hair cells required for hearing. In …
Atoh1: landscape for inner ear cell regeneration
R Hongmiao, L Wei, H Bing, DD Xiong… - Current gene …, 2014 - ingentaconnect.com
Hearing impairment is primarily attributed to inner ear hair cell (HC) defects that
subsequently lead to spiral ganglion neuron (SGN) loss. The HC loss cannot be self …
subsequently lead to spiral ganglion neuron (SGN) loss. The HC loss cannot be self …
Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo
MC Kelly, Q Chang, A Pan, X Lin… - Journal of …, 2012 - Soc Neuroscience
Hearing impairment due to the loss of sensory hair cells is permanent in humans.
Considerable interest targets the hair cell differentiation factor Atoh1 as a potential tool with …
Considerable interest targets the hair cell differentiation factor Atoh1 as a potential tool with …
[HTML][HTML] Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells
D Scheffer, C Sage, DP Corey, V Pingault - FEBS letters, 2007 - Elsevier
ATOH1 is a basic Helix-Loop-Helix transcription factor crucial for hair cell (HC) differentiation
in the inner ear. In order to identify ATOH1 target genes, we performed a genome-wide …
in the inner ear. In order to identify ATOH1 target genes, we performed a genome-wide …
Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea
ZP Stojanova, T Kwan, N Segil - Development, 2015 - journals.biologists.com
In the developing cochlea, sensory hair cell differentiation depends on the regulated
expression of the bHLH transcription factor Atoh1. In mammals, if hair cells die they do not …
expression of the bHLH transcription factor Atoh1. In mammals, if hair cells die they do not …
[HTML][HTML] Atoh1 expression levels define the fate of rat cochlear nonsensory epithelial cells in vitro
WW Luo, JM Yang, Z Han… - Molecular …, 2014 - spandidos-publications.com
Atonal homolog 1 (Atoh1) is a basic helix-loop-helix transcription factor that is essential for
inner ear hair cell differentiation. Previous studies have reported that Atoh1 gene transfer …
inner ear hair cell differentiation. Previous studies have reported that Atoh1 gene transfer …