Nanotechnology-based siRNA delivery strategies for treatment of triple negative breast cancer

R Chadar, P Kesharwani - International Journal of Pharmaceutics, 2021 - Elsevier
Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by
absence of estrogen (ER) receptor, progesterone (PR) receptor, and human epidermal …

[HTML][HTML] Bioengineered siRNA-based nanoplatforms targeting molecular signaling pathways for the treatment of triple negative breast cancer: preclinical and clinical …

D Hattab, A Bakhtiar - Pharmaceutics, 2020 - mdpi.com
Triple negative breast cancer (TNBC) is one of the most aggressive types of breast cancer.
Owing to the absenteeism of hormonal receptors expressed at the cancerous breast cells …

[HTML][HTML] siRNA-based nanocarriers for targeted drug delivery to control breast cancer

S Ashique, B Almohaywi, N Haider, S Yasmin… - Advances in Cancer …, 2022 - Elsevier
Breast cancer is a challenging health issue in women and the second-leading cause of
mortality around world. In this review, we addressed beneficial role of siRNA to control …

Nanocarriers for delivery of siRNA and co-delivery of siRNA and other therapeutic agents

J Zhao, SS Feng - Nanomedicine, 2015 - Taylor & Francis
A major problem in cancer treatment is the multidrug resistance. siRNA inhibitors have great
advantages to solve the problem, if the bottleneck of their delivery could be well addressed …

Nano-drug delivery system: a promising approach against breast cancer

JA Malik, JA Ansari, S Ahmed, A Khan… - Therapeutic …, 2023 - Taylor & Francis
Breast cancer (BC) is among the most frequent malignancies women face around the globe.
Nanotherapeutics are constantly evolving to overcome the limitations of conventional …

Recent advancements in the design of nanodelivery systems of siRNA for cancer therapy

DN Yadav, MS Ali, AM Thanekar, SV Pogu… - Molecular …, 2022 - ACS Publications
RNA interference (RNAi) has increased the possibility of restoring RNA drug targets for
cancer treatment. Small interfering RNA (siRNA) is a promising therapeutic RNAi tool that …

Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances

NS Gandhi, RK Tekade, MB Chougule - Journal of Controlled Release, 2014 - Elsevier
Chemotherapeutic agents have certain limitations when it comes to treating cancer, the most
important being severe side effects along with multidrug resistance developed against them …

[HTML][HTML] Nanomedicine-based delivery strategies for breast cancer treatment and management

P Tagde, A Najda, K Nagpal, GT Kulkarni… - International journal of …, 2022 - mdpi.com
Breast cancer is one of the most common types of cancer among women globally. It is
caused by mutations in the estrogen/progesterone receptors and conventional treatment …

[HTML][HTML] Nano-formulated siRNA-based therapeutic approaches for cancer therapy

D Jain, SK Prajapati, A Jain, R Singhal - Nano Trends, 2023 - Elsevier
RNAi is a remarkable treatment strategy to knock down gene overexpression in a variety of
disorders, including cancers. RNAi processes allow siRNAs to detect and degrade a …

Formulation and in vitro evaluation of a siRNA delivery nanosystem decorated with gH625 peptide for triple negative breast cancer theranosis

SB Djemaa, S David, K Hervé-Aubert, A Falanga… - European Journal of …, 2018 - Elsevier
The development of an efficient small interfering RNA (siRNA) delivery system has held
scientists interest since the discovery of the RNA interference mechanism (RNAi). This …